CALD1 Antibody

Code: CSB-PA004441DSR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q05682

Target Names

CALD1

Alternative Names

CAD antibody; CALD 1 antibody; CALD1 antibody; CALD1_HUMAN antibody; Caldesmon 1 antibody; Caldesmon 1 Isoform 1 antibody; Caldesmon 1 Isoform 2 antibody; Caldesmon 1 Isoform 3 antibody; Caldesmon 1 Isoform 4 antibody; Caldesmon 1 Isoform 5 antibody; Caldesmon antibody; Caldesmon1 antibody; CDM antibody; H CAD antibody; HCAD antibody; L CAD antibody; LCAD antibody; MGC21352 antibody; NAG22 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Caldesmon protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA004441DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA004441DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004441DSR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.

Gene References into Functions

rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes. PMID:28255976
ANXA1 and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression. PMID:26657294
Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells. PMID:26430961
Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. PMID:24551305
caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum PMID:23196794
The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD. PMID:23418348
Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis. PMID:23575144
Caldesmon expression inhibits cancer cell migration and invasiveness. PMID:23265641
Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves PMID:22316291
Data found phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium. PMID:21738699
Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases. PMID:21626272
Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers. PMID:21184254
An involvement of caldesmon in the susceptibility to diabetic nephropathy in type 1 diabetes, independently from environmental glucose levels. PMID:20801058
h-caldesmon is useful in distinguishing atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma PMID:21131830
Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling PMID:19834610
Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID:19764806
The effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin, was studied. PMID:19889635
Specific but variable expression of h-caldesmon in leiomyosarcomas PMID:11759055
Motifs of the caldesmon family. PMID:11996092
results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes PMID:15047636
Alternative splicing contributes to dysfunctionality of glioma neovascularization. PMID:15161654
plays a crucial role in mediating the effects of Ca(2+)-calmodulin on the dynamics of the actin cytoskeleton PMID:15226374
unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells PMID:15456752
These results suggest that CaD is critically involved in the regulation of the actin cytoskeleton and migration in EC, and that p38 MAPK-mediated CaD phosphorylation may be involved in endothelial cytoskeletal remodeling. PMID:15521070
Serum l-CaD level as determined by ELISA is a good discriminator between glioma patients versus patients with other intracranial tumor. PMID:15958622
K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells PMID:16115893
Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. PMID:16800003
low molecular weight isoform CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature PMID:17582218
Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. PMID:17631293
A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three organs and may represent general cancer-related splicing events. PMID:18353764
GR directly bound to the two glucocorticoid-response element-like sequences in the human CALD1 promoter and transactivated the CALD1 gene, thereby up-regulating the CaD protein. PMID:18772142
Vaginal caldesmon expression is significantly decreased in women with anterior vaginal wall prolapse compared to normal subjects PMID:19582387

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber.

Protein Families

Caldesmon family

Tissue Specificity

High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Database Links

HGNC: 1441

UNIGENE: Hs.490203

KEGG: hsa:800

STRING: 9606.ENSP00000354826

OMIM: 114213

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