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Recombinant Human STEAP1 protein (STEAP1), partial-Detergent

Recombinant Human STEAP1 protein (STEAP1), partial-Detergent

Code: CSB-MP890691HU1-D

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Size:

20ug100ug1mg

US$725

Quantity:

Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: N-terminal Twin-Strep-tagged and C-terminal 10xHis-tagged

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Target Background

Product Details

Abbreviation

Recombinant Human STEAP1 protein, partial-Detergent

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

STEAP1

Uniprot NO.

Q9UHE8

Research Area

Epigenetics and Nuclear Signaling

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

2-339aa

Mol. Weight

44.2 kDa

Protein Length

Partial

Tag Info

N-terminal Twin-Strep-tagged and C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

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Target Background

Function(From Uniprot)

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.

Gene References into Functions

High STEAP1 expression is associated with prostate cancer. PMID:29464393
Data suggest a solid basis for further research into understanding how six-transmembrane epithelial antigen of prostate member 1 (STEAP1) activities may affect cancer progression. PMID:27792302
These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression PMID:25453051
Data indicate that six transmembrane epithelial antigen of the prostate 1 (STEAP1) is consistently overexpressed in malignant prostate tissue, namely adenocarcinoma and prostatic intraepithelial neoplasia (PIN) lesions. PMID:24239460
The findings provide evidence that STEAP1 is a biomarker of worse prognosis in prostate carcinomas patients. PMID:24025158
STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate. PMID:23060075
A total of 62.3% of the Ewing's Sarcoma samples displayed detectable STEAP1 expression with predominant localization of the protein at the plasma membrane. PMID:22317770
STEAP1 is associated with the invasive behavior and oxidative stress phenotype of Ewing tumors, an unanticipated oncogenic function of STEAP1. PMID:22080479
STEAP1 overexpression predicts improved outcome of Ewing's sarcoma patients, possibly due to enhanced sensitivity towards ROS-generating chemotherapeutics. PMID:22317770
EWS-FLI1 mediated overexpression of STEAP1 increases the invasiveness and oxidative stress levels of Ewing tumor cells. PMID:22080479
Data suggest that zoledronic acid may affect cancer cells also by targeting the gene expression of STEAP. PMID:19915386
Peptide STEAP-292.2L (MLAVFLPIV) may have potential as an antitumor peptide vaccine. PMID:15958640
STEAP mRNA is used here as a marker to evaluate biological samples from individuals suspected of having cancers, and may provide prognostic information useful in defining appropriate therapeutic options. PMID:18793824
STEAP1 is over-expressed in breast cancer and down-regulated by 17beta-estradiol. PMID:18958632
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID:19196137