ADAM9

ADAM9, full name A Disintegrin And Metalloproteinase Domain 9, is also known as MDC9 or Meltrin gamma. As a transmembrane metalloproteinase, it combines disintegrin and metalloprotease domains to mediate cell-cell/matrix adhesion and cleave substrates like pro-HB-EGF and pro-MMPs, regulating EGFR and PI3K/Akt signaling pathways.
Overexpression of ADAM9 correlates with non-small cell lung cancer, colorectal cancer, and breast cancer, promoting tumor invasion, metastasis, and angiogenesis. Preclinical studies are exploring ADAM9-targeted therapies—including monoclonal antibodies and small-molecule inhibitors—to block its proteolytic activity and suppress tumor progression.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU). The EC₅₀ is 0.9401-1.088 ng/mL.

ADAM9 Recombinant Monoclonal Antibody(CSB-RA618774MA1HU)

Validated Data

The Binding Activity of Human ADAM9 with Anti-ADAM9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ADAM9 (CSB-MP618774HU) at 2 μg/mL can bind Anti-ADAM9 recombinant antibody. The EC₅₀ is 0.9401-1.088 ng/mL.

The purity of ADAM9 was greater than 95% as determined by SEC-HPLC

ADAM9 Antibody(CSB-PA618774ESR2HU)

Validated Data

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA618774ESR2HU at dilution of 1:100

Human A Disintegrin And Metalloprotease 9,ADAM9 ELISA Kit(CSB-E11904h)

Validated Data

Code: CSB-E11904h

Size: 96T,5×96T,10×96T

Sensitivity: 15.6 pg/mL

Detection Range: 62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following ADAM9 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ADAM9 Antibodies

ADAM9 Proteins

ADAM9 ELISA Kits

ADAM9 Antibodies

ADAM9 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA618774ESR1HU	ADAM9 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA618774ESR2HU	ADAM9 Antibody	Human	ELISA, IHC
CSB-RA618774MB1HU	ADAM9 (izeltabart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA618774MA1HU	ADAM9 Recombinant Monoclonal Antibody	Human	ELISA

ADAM9 Proteins

ADAM9 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-MP7133MOVd7	Recombinant Macaca fascicularis ADAM metallopeptidase domain 9 (ADAM9), partial (Active)	Mammalian cell
CSB-MP7133MOVk7-B	Recombinant Macaca fascicularis ADAM metallopeptidase domain 9 (ADAM9), partial, Biotinylated (Active)	Mammalian cell

ADAM9 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP618774HU CSB-EP618774HU CSB-BP618774HU CSB-MP618774HU CSB-EP618774HU-B	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP618774HU1	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Partial	Mammalian cell
CSB-MP618774HUk7-B	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), partial, Biotinylated	Mammalian cell
CSB-MP618774HU	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9),Partial (Active)	Mammalian cell

ADAM9 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP730719MO CSB-EP730719MO CSB-BP730719MO CSB-MP730719MO CSB-EP730719MO-B	Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 9 (Adam9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP730719MO	Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 9 (Adam9), Partial	Mammalian cell

ADAM9 ELISA Kit

ADAM9 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E11904h	Human A Disintegrin And Metalloprotease 9,ADAM9 ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates, ascitic fluid	15.6 pg/mL

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ADAM9

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