ARID1B

ARID1B encodes AT-rich interactive domain-containing protein 1B, a subunit of the SWI/SNF chromatin remodeling complex. It regulates gene expression by altering chromatin structure, often acting as a tumor suppressor. Key aliases include BAF250b and OSA2.
ARID1B dysfunction impacts pathways like PI3K/AKT and Wnt/β-catenin, contributing to cancers (ovarian, gastric), intellectual disability, and Coffin-Siris syndrome. Drug development focuses on synthetic lethal interactions with EZH2 or PARP inhibitors, though clinical trials are early-stage.