BAP1

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.

The following BAP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BAP1 Antibodies

BAP1 Proteins

BAP1 Antibodies

BAP1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA002556XA01DIL	bap1 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

BAP1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002556GA01HU	BAP1 Antibody	Human	ELISA,WB
CSB-PA849763ESR2HU	BAP1 Antibody	Human	ELISA, WB
CSB-PA985124	BAP1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

BAP1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA846376XA01DOA	BAP1 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

BAP1 Proteins

BAP1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP682744CH CSB-EP682744CH CSB-BP682744CH CSB-MP682744CH CSB-EP682744CH-B	Recombinant Chicken Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Branchiostoma floridae (Florida lancelet) (Amphioxus)

Code	Product Name	Source
CSB-YP002556BVY CSB-EP002556BVY CSB-BP002556BVY CSB-MP002556BVY CSB-EP002556BVY-B	Recombinant Branchiostoma floridae Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP002556DIL CSB-EP002556DIL CSB-BP002556DIL CSB-MP002556DIL CSB-EP002556DIL-B	Recombinant Danio rerio Ubiquitin carboxyl-terminal hydrolase BAP1 (bap1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP849763HU CSB-EP849763HU CSB-BP849763HU CSB-MP849763HU CSB-EP849763HU-B	Recombinant Human Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP002556RA CSB-EP002556RA CSB-BP002556RA CSB-MP002556RA CSB-EP002556RA-B	Recombinant Rat Ubiquitin carboxyl-terminal hydrolase BAP1 (Bap1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP846376DOA CSB-EP846376DOA CSB-BP846376DOA CSB-MP846376DOA CSB-EP846376DOA-B	Recombinant Arabidopsis thaliana BON1-associated protein 1 (BAP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP721087XBF CSB-EP721087XBF CSB-BP721087XBF CSB-MP721087XBF CSB-EP721087XBF-B	Recombinant Xenopus tropicalis Ubiquitin carboxyl-terminal hydrolase BAP1 (bap1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP002556BO CSB-EP002556BO CSB-BP002556BO CSB-MP002556BO CSB-EP002556BO-B	Recombinant Bovine Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP858174MO CSB-EP858174MO CSB-BP858174MO CSB-MP858174MO CSB-EP858174MO-B	Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase BAP1 (Bap1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAP1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP690442XBE CSB-EP690442XBE CSB-BP690442XBE CSB-MP690442XBE CSB-EP690442XBE-B	Recombinant Xenopus laevis Ubiquitin carboxyl-terminal hydrolase BAP1 (bap1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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