BCL6

BCL6, also known as B-cell lymphoma 6, is a proto-oncogene that functions as a transcriptional repressor. It plays a critical role in the regulation of humoral immunity by initiating and maintaining germinal centers. BCL6 represses genes such as ATR, TP53, CDKN1A, and EP300 to enable proliferation and survival during affinity maturation. It also represses terminal differentiation factors like IRF4 and PRDM1. BCL6 is associated with various cancers, including diffuse large B-cell lymphoma (DLBCL), acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and glioblastoma (GBM). Targeting BCL6 has emerged as a potential therapeutic strategy, with inhibitors like peptide inhibitors and small molecules being explored for their efficacy in treating these cancers.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BCL6 Recombinant Monoclonal Antibody(CSB-RA131953A0HU)

Validated Data

IHC image of CSB-RA131953A0HU diluted at 1:33 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.73% DAB.

Overlay Peak curve showing Jurkat cells stained with CSB-RA131953A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human B-cell leukemia/lymphoma 6,Bcl6 ELISA Kit(CSB-E14975h)

Validated Data

Code: CSB-E14975h

Size: 96T,5×96T,10×96T

Sensitivity: 4.68 pg/mL

Detection Range: 18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following BCL6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BCL6 Antibodies

BCL6 Proteins

BCL6 ELISA Kits

BCL6 Antibodies

BCL6 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA935424	BCL6 (Ab-333) Antibody	Human,Mouse	ELISA,WB
CSB-PA005439	BCL6 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA040219	Phospho-BCL6 (S333) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA040220	BCL6 Antibody	Human,Mouse	IHC, ELISA
CSB-PA040221	BCL6 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA908823	BCL6 Antibody	Human,Mouse	ELISA,IHC
CSB-PA171912	BCL6 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA002625ZA01HU	BCL6 Antibody	Homo sapiens	ELISA, WB (ensure identification of antigen)
CSB-RA131953A0HU	BCL6 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC

BCL6 Proteins

BCL6 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP736607CH CSB-EP736607CH CSB-BP736607CH CSB-MP736607CH CSB-EP736607CH-B	Recombinant Chicken B-cell lymphoma 6 protein homolog (BCL6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BCL6 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP002625HU CSB-EP002625HU CSB-BP002625HU CSB-MP002625HU CSB-EP002625HU-B	Recombinant Human B-cell lymphoma 6 protein (BCL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP002625HU	Recombinant Human B-cell lymphoma 6 protein (BCL6)	E.coli
CSB-EP002625HU1	Recombinant Human B-cell lymphoma 6 protein (BCL6), partial	E.coli
CSB-EP002625HUe1	Recombinant Human B-cell lymphoma 6 protein (BCL6)	E.coli
CSB-EP002625HUa0	Recombinant Human B-cell lymphoma 6 protein (BCL6)	E.coli

BCL6 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP002625MO CSB-EP002625MO CSB-BP002625MO CSB-MP002625MO CSB-EP002625MO-B	Recombinant Mouse B-cell lymphoma 6 protein homolog (Bcl6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BCL6 ELISA Kit

BCL6 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E14975h	Human B-cell leukemia/lymphoma 6,Bcl6 ELISA Kit	serum, plasma, tissue homogenates	4.68 pg/mL

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BCL6

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