BRD4

BRD4, a member of the bromine domain and ultra-terminal domain (BET) family, is a crucial regulator of gene expression that interacts with acetylated histones to modulate transcription. This protein utilizes its two bromine domains, BD1 and BD2, to bind acetylated histones, positioning itself at the promoter or enhancer regions of target genes and thereby facilitating their transcription. BRD4 also boosts RNA polymerase II activity by attracting transcription elongation factors and other regulators, promoting gene transcriptional elongation. It is instrumental in cellular processes like the cell cycle, proliferation, and apoptosis. Research indicates that BRD4's dysregulation is linked to the development of various cancers, such as acute myeloid leukemia, multiple myeloma, breast cancer, and glioblastoma. Its involvement extends to tumor cell proliferation and metastasis, as well as to DNA damage repair and telomere maintenance, making BRD4 a significant therapeutic target in tumor.