C3

C3, also known as Complement component 3 (C3, C3adesArg, C3bc), is one of the primary complement components in human plasma, produced by liver cells. C3 is a central protein in the complement system. Its mechanisms of action include serving as a pivotal component in the complement cascade, which can be activated through multiple pathways including the classical pathway, the alternative pathway, and the lectin pathway. Activation of C3 leads to its cleavage into two fragments, C3a and C3b. C3b is the effector fragment, which binds to pathogen surfaces, facilitating phagocytosis, while C3a acts as a potent anaphylatoxin.

C3 is a key component of the complement system and is involved in the body's immune defense mechanisms. Activation of C3 promotes the clearance of pathogens, enhances the recognition and phagocytosis of pathogens by phagocytes, and C3b fragments can also participate in the formation of the membrane attack complex (MAC), leading to the lysis of pathogen cells. Additionally, C3 is involved in regulating inflammatory responses and influences cell adhesion and intercellular interactions. Abnormal regulation of C3 is associated with various diseases, including autoimmune disorders, kidney diseases, and certain infectious diseases. As such, C3 is a potential target in immunological research and the treatment of related diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP105994h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) C3.

C3 Recombinant Monoclonal Antibody(CSB-RA303909A0HU)

Validated Data

Western Blot
Positive WB detected in: THP-1 whole cell lysate, K562 whole cell lysate
All lanes: C3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 188 kDa
Observed band size: 115 kDa

IHC image of CSB-RA303909A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10⁶ cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*10⁶ cells) used under the same conditions. Acquisition of >10,000 events was performed.

The following C3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

C3 Antibodies

C3 Proteins

C3 ELISA Kits

C3 Antibodies

C3 Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA360475HA01RA	C3 Antibody	Rat	ELISA
CSB-PA360475HB01RA	C3 Antibody, HRP conjugated	Rat	ELISA
CSB-PA360475HC01RA	C3 Antibody, FITC conjugated	Rat

C3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA10599D0Rb	C3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA10599B0Rb	C3 Antibody, HRP conjugated	Human	ELISA
CSB-PA10599A0Rb	C3 Antibody	Human	ELISA, IHC, IF
CSB-PA10599C0Rb	C3 Antibody, FITC conjugated	Human
CSB-EAP10599	C3 Antibody Pair	Human,Rat,Guinea pig,Bovine,Horse,Pig,Dog,Goat,Sheep	S-ELISA
CSB-RA303909A0HU	C3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC
CSB-RA699863A0HU	C3 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA355590MA1HU	C3 Recombinant Monoclonal Antibody	Human	ELISA, FC

C3 Antibodies for Bos taurus (Bovine)

Code	Product Name	Species Reactivity	Application
CSB-PA647263ZA01BO	C3 Antibody	Bos taurus	ELISA, WB (ensure identification of antigen)

C3 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA365507LA01MO	C3 Antibody	Mouse, Human	ELISA, WB
CSB-PA365507LB01MO	C3 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA365507LC01MO	C3 Antibody, FITC conjugated	Mouse
CSB-PA365507LD01MO	C3 Antibody, Biotin conjugated	Mouse	ELISA

C3 Antibodies for Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

Code	Product Name	Species Reactivity	Application
CSB-PA323391XA01CLR	C3 Antibody	Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)	ELISA, WB (ensure identification of antigen)

C3 Proteins

C3 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Code	Product Name	Source
CSB-YP311048OEI CSB-EP311048OEI CSB-BP311048OEI CSB-MP311048OEI CSB-EP311048OEI-B	Recombinant Oncorhynchus mykiss Complement C3 (c3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato pseudo-curly top virus (TPCTV)

Code	Product Name	Source
CSB-YP801533TDAC CSB-EP801533TDAC CSB-BP801533TDAC CSB-MP801533TDAC CSB-EP801533TDAC-B	Recombinant Tomato pseudo-curly top virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)

Code	Product Name	Source
CSB-YP339986TGS CSB-EP339986TGS CSB-BP339986TGS CSB-MP339986TGS CSB-EP339986TGS-B	Recombinant Tomato yellow leaf curl Sardinia virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP355590HU CSB-EP355590HU CSB-BP355590HU CSB-MP355590HU CSB-EP355590HU-B	Recombinant Human Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP355590HU	Recombinant Human Complement C3 (C3), partial	E.coli

C3 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP003888PI CSB-EP003888PI CSB-BP003888PI CSB-MP003888PI CSB-EP003888PI-B	Recombinant Pig Complement C3a anaphylatoxin (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP003888PI	Recombinant Pig Complement C3 (C3), partial	E.coli
CSB-YP003888PIa4	Recombinant Pig Complement C3 (C3), partial	Yeast
CSB-YP003888PI	Recombinant Pig Complement C3 (C3), partial	Yeast

C3 Proteins for Hathewaya limosa (Clostridium limosum)

Code	Product Name	Source
CSB-YP673832CEAI CSB-EP673832CEAI CSB-BP673832CEAI CSB-MP673832CEAI CSB-EP673832CEAI-B	Recombinant Mono-ADP-ribosyltransferase C3 (c3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP647263BO CSB-EP647263BO CSB-BP647263BO CSB-MP647263BO CSB-EP647263BO-B	Recombinant Bovine Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP647263BO	Recombinant Bovine Complement C3 (C3), partial	E.coli

C3 Proteins for Beet curly top virus (strain California/Logan) (BCTV)

Code	Product Name	Source
CSB-YP324435BFX CSB-EP324435BFX CSB-BP324435BFX CSB-MP324435BFX CSB-EP324435BFX-B	Recombinant Beet curly top virus Replication enhancer (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato yellow leaf curl Sardinia virus (TYLCSV)

Code	Product Name	Source
CSB-YP338820TGT CSB-EP338820TGT CSB-BP338820TGT CSB-MP338820TGT CSB-EP338820TGT-B	Recombinant Tomato yellow leaf curl Sardinia virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP319396GU CSB-EP319396GU CSB-BP319396GU CSB-MP319396GU CSB-EP319396GU-B	Recombinant Guinea pig Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

Code	Product Name	Source
CSB-YP702426MDAK CSB-EP702426MDAK CSB-BP702426MDAK CSB-MP702426MDAK CSB-EP702426MDAK-B	Recombinant Microplitis demolitor bracovirus Uncharacterized protein C3 (C3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP329415XBE CSB-EP329415XBE CSB-BP329415XBE CSB-MP329415XBE CSB-EP329415XBE-B	Recombinant Xenopus laevis Complement C3 (c3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)

Code	Product Name	Source
CSB-YP731478TBAX CSB-EP731478TBAX CSB-BP731478TBAX CSB-MP731478TBAX CSB-EP731478TBAX-B	Recombinant Tomato yellow leaf curl Sardinia virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Salmonella phage P22 (Bacteriophage P22)

Code	Product Name	Source
CSB-YP319647EDG CSB-EP319647EDG CSB-BP319647EDG CSB-MP319647EDG CSB-EP319647EDG-B	Recombinant Enterobacteria phage P22 Regulatory protein C3 (C3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Caiman crocodilus (Spectacled caiman) (Caiman sclerops)

Code	Product Name	Source
CSB-YP355757CAF CSB-EP355757CAF CSB-BP355757CAF CSB-MP355757CAF CSB-EP355757CAF-B	Recombinant Caiman crocodilus Ig heavy chain V region C3 (C3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato yellow leaf curl virus (strain Israel) (TYLCV)

Code	Product Name	Source
CSB-YP326697TGU CSB-EP326697TGU CSB-BP326697TGU CSB-MP326697TGU CSB-EP326697TGU-B	Recombinant Tomato yellow leaf curl virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP360475RA	Recombinant Rat Complement C3 (C3), partial	Yeast
CSB-YP360475RA CSB-EP360475RA CSB-BP360475RA CSB-MP360475RA CSB-EP360475RA-B	Recombinant Rat Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP003888RB CSB-EP003888RB CSB-BP003888RB CSB-MP003888RB CSB-EP003888RB-B	Recombinant Rabbit Complement C3 alpha chain (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Eptatretus burgeri (Inshore hagfish)

Code	Product Name	Source
CSB-YP310251EFF CSB-EP310251EFF CSB-BP310251EFF CSB-MP310251EFF CSB-EP310251EFF-B	Recombinant Eptatretus burgeri Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-EP365507MO	Recombinant Mouse Complement C3 (C3), partial	E.coli
CSB-YP365507MO CSB-EP365507MO CSB-BP365507MO CSB-MP365507MO CSB-EP365507MO-B	Recombinant Mouse Complement C3 (C3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

Code	Product Name	Source
CSB-YP323391CLR CSB-EP323391CLR CSB-BP323391CLR CSB-MP323391CLR CSB-EP323391CLR-B	Recombinant Clostridium botulinum D phage Mono-ADP-ribosyltransferase C3 (C3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato leaf curl virus (strain Australia) (ToLCV)

Code	Product Name	Source
CSB-YP334110TGF CSB-EP334110TGF CSB-BP334110TGF CSB-MP334110TGF CSB-EP334110TGF-B	Recombinant Tomato leaf curl virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 Proteins for Tomato yellow leaf curl China virus (TYLCCNV)

Code	Product Name	Source
CSB-YP887626TGAQ CSB-EP887626TGAQ CSB-BP887626TGAQ CSB-MP887626TGAQ CSB-EP887626TGAQ-B	Recombinant Tomato yellow leaf curl China virus Replication enhancer protein (C3, L3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C3 ELISA Kit

C3 ELISA Kit for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Sample Types	Sensitivity
CSB-E09283Rb	Rabbit Complement fragment 3a,C3a ELISA Kit	serum, plasma, tissue homogenates	1.56 ng/mL

C3 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E08666r	Rat Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.156 μg/mL
CSB-E08510r	Rat Complement fragment 3a,C3a ELISA Kit	serum, plasma, tissue homogenates	0.39 ng/mL

C3 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E08665h	Human Complement 3,C3 ELISA Kit	serum, plasma, cell culture supernates, urine, saliva	4.031 ng/mL
CSB-E08509h	Human Complement fragment 3a,C3a ELISA Kit	serum, plasma, tissue homogenates	7.81 ng/mL
CSB-E14213h	Human Complement Fragment 3d,C3d ELISA Kit	serum, plasma, tissue homogenates	0.039 μg/mL
CSB-E09303h	Human Complement fragment 3b,C3b ELISA Kit	serum, urine, cerebrospinal fluid (CSF), saliva	0.78 ng/mL

C3 ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E06920p	Pig Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL

C3 ELISA Kit for Monkey

Code	Product Name	Sample Types	Sensitivity
CSB-E16528Mk	Monkey Complement 3(C3)ELISA Kit	serum, plasma, cell culture supernates	1.17 ng/mL

C3 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E08667m	Mouse Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	23.44 ng/mL
CSB-E08511m	Mouse Complement fragment 3a,C3a ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	0.039 ng/mL

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