C5AR1

C5AR1, complement component 5a receptor 1, alias CD88. it is a G protein-coupled receptor expressed mainly on granulocytes, monocytes, dendritic cells and myeloid-derived suppressor cells (MDSC) as well as tumor cells.
The mechanism of action of C5AR1 is to activate downstream G protein and β-inhibin signaling pathways by binding to the complement activation fragment C5a, thus playing a key role in the innate immune response. Dysfunction of the C5a-C5aR1 axis is associated with many inflammatory and immune-mediated diseases, including tumor development.
C5AR1 is not only involved in the activation and chemotaxis of immune cells, but is also associated with the immunoregulation of the tumor microenvironment, and its expression level is elevated in a variety of tumors, which can be predictive of biomarkers of disease progression and prognosis, as well as a potential therapeutic target.