CCL2

CCL2, or chemokine ligand 2, alias MCP-1, SCYA2, MCAF, SMC-CF. The mechanism of action of CCL2 is mainly through binding to its receptor CCR2, which activates the cell migration process, especially plays a key role in the migration of blood monocytes, memory T lymphocytes and natural killer cells.
CCL2 also binds to atypical chemokine receptors ACKR1, ACKR2 and glycosaminoglycan chains of proteoglycans. CCL2 has profound effects on immune cell behavior, including leukocyte adhesion, polarization, secretion of effector molecules, autophagy, killing, and survival, and especially plays a crucial role in normal recruitment of immune cells, tissue remodeling, angiogenesis, and other physiological processes.
Abnormal expression of CCL2 is closely associated with the onset and progression of various diseases such as arthritis and atherosclerosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCL2 Recombinant Monoclonal Antibody(CSB-RA004783MA1HU)

Validated Data

IHC image of CSB-RA004783MA1HU diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.

The following CCL2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CCL2 Antibodies

CCL2 Proteins

CCL2 ELISA Kits

CCL2 Antibodies

CCL2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA05865C0Rb	CCL2 Antibody, FITC conjugated	Human
CSB-PA05865B0Rb	CCL2 Antibody, HRP conjugated	Human	ELISA
CSB-PA05865A0Rb	CCL2 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA05864A0Rb	CCL2 Antibody	Human	ELISA, IHC, IF
CSB-PA05864B0Rb	CCL2 Antibody, HRP conjugated	Human	ELISA
CSB-PA662351	CCL2 Antibody	Human	ELISA,IHC
CSB-PA012674	CCL2 Antibody	Human	ELISA,IHC
CSB-RA004783MA1HU	CCL2 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA004783MB1HU	CCL2 (carlumab Biosimilar) Recombinant Monoclonal Antibody	Human

CCL2 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA09047A0Rb	Ccl2 Antibody	Mouse	ELISA, IF
CSB-EAP09047	Ccl2 Antibody Pair	Human,Mouse,Bovine,Horse,Pig,Dog,Duck	S-ELISA
CSB-PA004783ZA01MO	Ccl2 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

CCL2 Proteins

CCL2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP004783DO CSB-EP004783DO CSB-BP004783DO CSB-MP004783DO CSB-EP004783DO-B	Recombinant Dog C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP886938HO CSB-EP886938HO CSB-BP886938HO CSB-MP886938HO CSB-EP886938HO-B	Recombinant Horse C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP004783MOV CSB-EP004783MOV CSB-BP004783MOV CSB-MP004783MOV CSB-EP004783MOV-B	Recombinant Macaca fascicularis C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP004783RA CSB-EP004783RA CSB-BP004783RA CSB-MP004783RA CSB-EP004783RA-B	Recombinant Rat C-C motif chemokine 2 (Ccl2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP004783RB CSB-EP004783RB CSB-BP004783RB CSB-MP004783RB CSB-EP004783RB-B	Recombinant Rabbit C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP004783HU CSB-EP004783HU CSB-BP004783HU CSB-MP004783HU CSB-EP004783HU-B	Recombinant Human C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP000821HU	Recombinant Human C-C motif chemokine 2 protein (CCL2) (Active)	E.coli
CSB-EP004783HU	Recombinant Human C-C motif chemokine 2 (CCL2)	E.coli
CSB-EP004783HUb1	Recombinant Human C-C motif chemokine 2 (CCL2)	E.coli
CSB-EP004783HUf0	Recombinant Human C-C motif chemokine 2 (CCL2)	E.coli

CCL2 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP004783PI CSB-EP004783PI CSB-BP004783PI CSB-MP004783PI CSB-EP004783PI-B	Recombinant Pig C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP712922PYX CSB-EP712922PYX CSB-BP712922PYX CSB-MP712922PYX CSB-EP712922PYX-B	Recombinant Pongo abelii C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP004783MOW CSB-EP004783MOW CSB-BP004783MOW CSB-MP004783MOW CSB-EP004783MOW-B	Recombinant Macaca mulatta (Rhesus macaque) C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP004783BO CSB-EP004783BO CSB-BP004783BO CSB-MP004783BO CSB-EP004783BO-B	Recombinant Bovine C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP600526GU CSB-EP600526GU CSB-BP600526GU CSB-MP600526GU CSB-EP600526GU-B	Recombinant Guinea pig C-C motif chemokine 2 (CCL2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCL2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP004783MO CSB-EP004783MO CSB-BP004783MO CSB-MP004783MO CSB-EP004783MO-B	Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004783MO	Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial	E.coli

CCL2 ELISA Kit

CCL2 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Sample Types	Sensitivity
CSB-E15747c	Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit	serum, plasma, tissue homogenates	0.147 ng/mL

CCL2 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E07429r	Rat monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, tissue homogenates	7.8 pg/mL
CSB-E07429r-IS	Rat monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	1.95 pg/mL

CCL2 ELISA Kit for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Sample Types	Sensitivity
CSB-E06921Rb	Rabbit monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit	serum, plasma, tissue homogenates	5.87 pg/mL

CCL2 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E04655h	Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tissue homogenates.	1.56 pg/ml.

CCL2 ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E13178p	Pig monocyte chemotactic protein 1,MCP1 ELISA Kit	serum, plasma	7.81 pg/mL

CCL2 ELISA Kit for Monkey

Code	Product Name	Sample Types	Sensitivity
CSB-E10045Mo	Monkey monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL

CCL2 ELISA Kit for Bos taurus (Bovine)

Code	Product Name	Sample Types	Sensitivity
CSB-E16221B	Bovine monocyte chemotactic protein 1/monocyte chemotactic and activating factor,(MCP-1/CCL2/MCAF)ELISA Kit	serum, plasma, tissue homogenates	0.039 ng/mL

CCL2 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E07430m	Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, tissue homogenates	19.5 pg/mL

CCL2 ELISA Kit for Cavia porcellus (Guinea pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E13559Gp	Guinea pig monocyte chemotactic protein 1,MCP1 ELISA Kit	serum, plasma, tissue homogenates	5.8 pg/mL

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