CCL8

CCL8, C-C motif chemokine 8, also known as HC14, MCP2, MCP-2, SCYA8, SCYA10. CCL8 is a protein encoded by the CCL8 gene located on human chromosome 17.
CCL8 is a small-molecule cytokine belonging to the CC chemokine family that is expressed predominantly in small intestinal and peripheral blood cells. CCL8 binds to a wide variety of chemokine cell surface receptors, such as CCR1, CCR2B, CCR3, and CCR5, and acts as a chemoattractant to attract monocytes, lymphocytes, basophils, and eosinophils, among others, to mediate the inflammatory host response. CCL8 plays an important immunomodulatory role in a variety of physiological and pathological processes, including inflammatory responses, anti-tumor immunity and graft-versus-host disease.