CD200

CD200, also known as OX-2 membrane glycoprotein, is a type 1 membrane glycoprotein. It functions by binding to its receptor CD200R, which is expressed on myeloid and lymphoid cells. This interaction inhibits the activation of immune cells and helps maintain immune homeostasis. CD200 is involved in multiple signaling pathways, including those related to the regulation of the immune response.
In terms of disease association, abnormal CD200 expression has been linked to various conditions such as autoimmune diseases and cancers. In autoimmune diseases, its down - regulation may lead to over - active immune responses. In cancer, high CD200 expression can help tumors evade the immune system. Currently, there are ongoing efforts in drug development targeting the CD200 - CD200R axis to modulate immune responses for therapeutic purposes.