CD58

CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), is a well - recognized cell surface glycoprotein. It has no widely - known other common aliases. CD58 binds to CD2 on T and NK cells, playing a key role in cell - cell adhesion and costimulatory activation. This interaction is involved in the T - cell receptor signaling pathway, enhancing immune responses.
CD58 is associated with various diseases, including autoimmune diseases due to its role in immune regulation, as well as some types of cancer where abnormal expression may promote tumor immune escape. In drug development, research is ongoing to target the CD58 - CD2 interaction for immunotherapy, aiming to enhance anti - tumor immunity and manage autoimmune disorders.