Cyclin-Dependent Kinase 1 (CDK1), also known as CDC2 or p34cdc2, is a key regulator of the eukaryotic cell cycle. It forms active complexes with cyclins (notably cyclin B) to drive the G2-to-M phase transition, phosphorylating substrates like histone H1 and lamins to trigger nuclear envelope breakdown and chromosome condensation.
Aberrant CDK1 activation contributes to cancers such as breast and lung cancer by promoting uncontrolled cell division. Small-molecule inhibitors like RO-3306 are used as research tools and are under preclinical study for cancer therapy, often in combination with other agents to boost anti-tumor effects.
Popular
Product:
Recombinant Human Cyclin-dependent kinase 1 (CDK1)(CSB-EP361848HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP361848HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDK1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP361848HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDK1.
CDK1 Antibody(CSB-PA361848LA01HU)
Validated Data
IHC image of CSB-PA361848LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA361848LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
The following CDK1
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
CDK1 Proteins
CDK1 Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)
CDK1 Proteins for Gallus gallus (Chicken)
CDK1 Proteins for Homo sapiens (Human)
CDK1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
CDK1 Proteins for Bos taurus (Bovine)
CDK1 Proteins for Carassius auratus (Goldfish)
CDK1 Proteins for Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus)
CDK1 Proteins for Rattus norvegicus (Rat)
CDK1 Proteins for Oryzias luzonensis (Luzon ricefish)
CDK1 Proteins for Rana dybowskii (Dybovsky's frog) (Korean brown frog)
CDK1 Proteins for Oryzias curvinotus (Hynann ricefish) (Aplocheilus curvinotus)
CDK1 Proteins for Drosophila melanogaster (Fruit fly)
CDK1 Proteins for Mus musculus (Mouse)
CDK1 Proteins for Dictyostelium discoideum (Slime mold)
