CDK2

CDK2, known as cyclin-dependent kinase 2, is a serine/threonine protein kinase that plays a pivotal role in the regulation of the cell cycle. This enzyme, encoded by the CDK2 gene, interacts with cyclins to form active complexes. These complexes phosphorylate specific substrates, facilitating the cell cycle's transition from the G1 phase to the S phase, a process critical for DNA replication and cell division. The proper functioning of CDK2 is imperative for the cell cycle's integrity, and its dysregulation is often implicated in pathologies such as cancer. Consequently, CDK2 is a significant target for therapeutic interventions and a focal point in drug development aimed at treating malignancies.