CFTR

CFTR, the cystic fibrosis transmembrane conductance regulator, is an ATP-gated ion channel widely expressed in epithelial cell membranes and belongs to the ATP-binding cassette transporter superfamily.The mechanism of action of CFTR involves the dimerisation of two nucleotide-binding structural domains (NBDs) and subsequent conformational changes that are governed by the hydrolysis of ATP, which regulates chloride ion conductance. Abnormal function of CFTR leads to cystic fibrosis, a common genetic disorder characterised by a dysregulation of water-salt homeostasis in several tissues and organs of the body, causing symptoms such as malnutrition, liver disease, recurrent bacterial infections, chronic inflammation and respiratory failure. In a biological sense, CFTR is essential for maintaining salt and fluid homeostasis on epithelial cell membranes, and its normal function is important for preventing mucus plugging in the respiratory and digestive tracts, and for maintaining lung function and digestive health.

Validated Data

Code: CSB-EL005292HU

Size: 96T,5×96T,10×96T

Sensitivity: 7 pg/mL

Detection Range: 28 pg/mL-1800 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CFTR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CFTR Antibodies

CFTR Proteins

CFTR ELISA Kits

CFTR Antibodies

CFTR Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA282472XA01DIL	cftr Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

CFTR Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA001608	CFTR Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA940971	CFTR Antibody	Human	ELISA,IHC
CSB-PA968401	CFTR Antibody	Human	ELISA,IHC

CFTR Proteins

CFTR Proteins for Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)

Code	Product Name	Source
CSB-YP649286CYE CSB-EP649286CYE CSB-BP649286CYE CSB-MP649286CYE CSB-EP649286CYE-B	Recombinant Callicebus moloch Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP646912HO CSB-EP646912HO CSB-BP646912HO CSB-MP646912HO CSB-EP646912HO-B	Recombinant Horse Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)

Code	Product Name	Source
CSB-YP646918OFS CSB-EP646918OFS CSB-BP646918OFS CSB-MP646918OFS CSB-EP646918OFS-B	Recombinant Otolemur garnettii Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP754284PI CSB-EP754284PI CSB-BP754284PI CSB-MP754284PI CSB-EP754284PI-B	Recombinant Pig Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP643184PYX CSB-EP643184PYX CSB-BP643184PYX CSB-MP643184PYX CSB-EP643184PYX-B	Recombinant Pongo abelii Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Rhinolophus ferrumequinum (Greater horseshoe bat)

Code	Product Name	Source
CSB-YP645341RKD CSB-EP645341RKD CSB-BP645341RKD CSB-MP645341RKD CSB-EP645341RKD-B	Recombinant Rhinolophus ferrumequinum Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Papio anubis (Olive baboon)

Code	Product Name	Source
CSB-YP871315ERI CSB-EP871315ERI CSB-BP871315ERI CSB-MP871315ERI CSB-EP871315ERI-B	Recombinant Papio anubis Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Squalus acanthias (Spiny dogfish)

Code	Product Name	Source
CSB-YP005292FKW CSB-EP005292FKW CSB-BP005292FKW CSB-MP005292FKW CSB-EP005292FKW-B	Recombinant Squalus acanthias Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Loxodonta africana (African elephant)

Code	Product Name	Source
CSB-YP608845LJC CSB-EP608845LJC CSB-BP608845LJC CSB-MP608845LJC CSB-EP608845LJC-B	Recombinant Loxodonta africana Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP759053MOV CSB-EP759053MOV CSB-BP759053MOV CSB-MP759053MOV CSB-EP759053MOV-B	Recombinant Macaca fascicularis Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Trichosurus vulpecula (Brush-tailed possum)

Code	Product Name	Source
CSB-YP688569TQG CSB-EP688569TQG CSB-BP688569TQG CSB-MP688569TQG CSB-EP688569TQG-B	Recombinant Trichosurus vulpecula Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP005292MO CSB-EP005292MO CSB-BP005292MO CSB-MP005292MO CSB-EP005292MO-B	Recombinant Mouse Cystic fibrosis transmembrane conductance regulator (Cftr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP650850EQV CSB-EP650850EQV CSB-BP650850EQV CSB-MP650850EQV CSB-EP650850EQV-B	Recombinant Pan troglodytes Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Carollia perspicillata (Seba's short-tailed bat)

Code	Product Name	Source
CSB-YP650849CCAH CSB-EP650849CCAH CSB-BP650849CCAH CSB-MP650849CCAH CSB-EP650849CCAH-B	Recombinant Carollia perspicillata Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP005292HU CSB-EP005292HU CSB-BP005292HU CSB-MP005292HU CSB-EP005292HU-B	Recombinant Human Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur)

Code	Product Name	Source
CSB-YP650066MFU CSB-EP650066MFU CSB-BP650066MFU CSB-MP650066MFU CSB-EP650066MFU-B	Recombinant Microcebus murinus Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP005292BO CSB-EP005292BO CSB-BP005292BO CSB-MP005292BO CSB-EP005292BO-B	Recombinant Bovine Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP005292XBE CSB-EP005292XBE CSB-BP005292XBE CSB-MP005292XBE CSB-EP005292XBE-B	Recombinant Xenopus laevis Cystic fibrosis transmembrane conductance regulator (cftr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

Code	Product Name	Source
CSB-YP639482DSU CSB-EP639482DSU CSB-BP639482DSU CSB-MP639482DSU CSB-EP639482DSU-B	Recombinant Chlorocebus aethiops Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Callithrix jacchus (White-tufted-ear marmoset)

Code	Product Name	Source
CSB-YP650851CYL CSB-EP650851CYL CSB-BP650851CYL CSB-MP650851CYL CSB-EP650851CYL-B	Recombinant Callithrix jacchus Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP736031DO CSB-EP736031DO CSB-BP736031DO CSB-MP736031DO CSB-EP736031DO-B	Recombinant Dog Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

Code	Product Name	Source
CSB-YP639486GGZ CSB-EP639486GGZ CSB-BP639486GGZ CSB-MP639486GGZ CSB-EP639486GGZ-B	Recombinant Gorilla gorilla gorilla Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP005292SH CSB-EP005292SH CSB-BP005292SH CSB-MP005292SH CSB-EP005292SH-B	Recombinant Sheep Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Macaca nemestrina (Pig-tailed macaque)

Code	Product Name	Source
CSB-YP874690MOX CSB-EP874690MOX CSB-BP874690MOX CSB-MP874690MOX CSB-EP874690MOX-B	Recombinant Macaca nemestrina Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP005292RA CSB-EP005292RA CSB-BP005292RA CSB-MP005292RA CSB-EP005292RA-B	Recombinant Rat Cystic fibrosis transmembrane conductance regulator (Cftr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP005292RB CSB-EP005292RB CSB-BP005292RB CSB-MP005292RB CSB-EP005292RB-B	Recombinant Rabbit Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Macaca fuscata fuscata (Japanese macaque)

Code	Product Name	Source
CSB-YP748697MMX CSB-EP748697MMX CSB-BP748697MMX CSB-MP748697MMX CSB-EP748697MMX-B	Recombinant Macaca fuscata fuscata Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR Proteins for Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)

Code	Product Name	Source
CSB-YP651627DKL CSB-EP651627DKL CSB-BP651627DKL CSB-MP651627DKL CSB-EP651627DKL-B	Recombinant Didelphis marsupialis virginiana Cystic fibrosis transmembrane conductance regulator (CFTR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFTR ELISA Kit

CFTR ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL005292HU	Human Cystic fibrosis transmembrane conductance regulator(CFTR) ELISA kit	serum, plasma, tissue homogenates, cell lysates	7 pg/mL

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CFTR

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