CHRNA7

CHRNA7 encodes the alpha7 nicotinic acetylcholine receptor (α7 nAChR), a pentameric ligand-gated ion channel with high calcium permeability. Common aliases include nAChRα7 and CHRNA7. It mediates cholinergic signaling, regulating neurotransmission, synaptic plasticity, and immune cell activation—critical for cognitive functions (memory, attention) in the central nervous system and anti-inflammatory responses in peripheral tissues.
α7 nAChR participates in pathways like the cholinergic anti-inflammatory axis, PI3K/Akt, and MAPK. Dysregulation links to schizophrenia (cognitive deficits), Alzheimer’s disease (amyloid-β clearance), epilepsy, and inflammatory disorders. Drug development includes positive allosteric modulators (e.g., PNU-120596) in clinical trials for schizophrenia; agonists are explored for neuroprotection, though selectivity and blood-brain barrier penetration remain key challenges.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CHRNA7 Antibody(CSB-PA969473)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA969473(CHRFAM7A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA969473(CHRFAM7A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA969473(CHRFAM7A Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

The following CHRNA7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CHRNA7 Antibodies

CHRNA7 Proteins

CHRNA7 Antibodies

CHRNA7 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA969473	CHRNA7 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA188517	CHRNA7 Antibody	Human, Mouse, Rat	ELISA, WB

CHRNA7 Proteins

CHRNA7 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP005393CH CSB-EP005393CH CSB-BP005393CH CSB-MP005393CH CSB-EP005393CH-B	Recombinant Chicken Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRNA7 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP005393HU CSB-EP005393HU CSB-BP005393HU CSB-MP005393HU CSB-EP005393HU-B	Recombinant Human Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005393HUa0	Recombinant Human Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	E.coli
CSB-EP005393HU-B	Recombinant Human Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial, Biotinylated	E.coli
CSB-EP005393HUg2	Recombinant Human Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	E.coli
CSB-CF005393HU(A4)c7	Recombinant Human Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)	in vitro E.coli expression system

CHRNA7 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP005393MOW CSB-EP005393MOW CSB-BP005393MOW CSB-MP005393MOW CSB-EP005393MOW-B	Recombinant Macaca mulatta Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRNA7 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP005393BO CSB-EP005393BO CSB-BP005393BO CSB-MP005393BO CSB-EP005393BO-B	Recombinant Bovine Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRNA7 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP005393MO CSB-EP005393MO CSB-BP005393MO CSB-MP005393MO CSB-EP005393MO-B	Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-7 (Chrna7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005393MOc7	Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-7 (Chrna7), partial	E.coli
CSB-EP005393MO(M1)	Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-7 (Chrna7) (C212A), partial	E.coli
CSB-EP005393MO(M2)	Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-7 (Chrna7) (C212A, C213A), partial	E.coli
CSB-EP005393MO	Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-7 (Chrna7), partial	E.coli

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily?Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

CHRNA7

Popular Product: