CTLA4

CTLA4, or CD152, is a transmembrane protein predominantly expressed by activated T cells and encoded by the CTLA4 gene. It curbs T cell activation and proliferation by engaging with B7 family members like CD80 and CD86, modulating immune responses. CTLA4's modulation is significant in autoimmune and anti-tumor immunity, with its expression levels impacting immune tolerance and pathogenesis. CTLA4 dysregulation is associated with autoimmune diseases such as lupus and rheumatoid arthritis, and it's a target for immune checkpoint inhibitor therapies, with drugs like Ipilimumab used in melanoma treatments.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

The purity of CTLA4 was greater than 90% as determined by SEC-HPLC.

CTLA4 Recombinant Monoclonal Antibody(CSB-RA213310A0HU)

Validated Data

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following CTLA4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CTLA4 Antibodies

CTLA4 Proteins

CTLA4 ELISA Kits

CTLA4 Antibodies

CTLA4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006163KA01HU	CTLA4 Antibody	Human	ELISA,WB,IHC
CSB-PA224600	CTLA4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA252417	CTLA4 Antibody	Human	IHC,ELISA
CSB-PA006163LA01HU	CTLA4 Antibody	Human	ELISA, IF
CSB-PA006163LB01HU	CTLA4 Antibody, HRP conjugated	Human	ELISA
CSB-RA213310A0HU	CTLA4 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-MA006163A0m	CTLA4 Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA006163MA1HU	CTLA4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IF, FC
CSB-RA006163MA2HU	CTLA4 Recombinant Monoclonal Antibody	Human, Peptostreptococcus magnus	ELISA
CSB-RA006163MB16HU	CTLA4 (Tuvonralimab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB17HU	CTLA4 (YH-001 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB18HU	CTLA4 (Zalifrelimab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB1HU	CTLA4 (Tremelimumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB3HU	CTLA4 (ADG-116 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB4HU	CTLA4 (BAT-4706 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB5HU	CTLA4 (BMS-986218 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB6HU	CTLA4 (Botensilimab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB7HU	CTLA4 (Evalstotug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB8HU	CTLA4 (GIGA-564 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB9HU	CTLA4 (Gotistobart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB10HU	CTLA4 (JS-007 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB11HU	CTLA4 (LM-168 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB12HU	CTLA4 (Quavonlimab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB13HU	CTLA4 (WBP299 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB14HU	CTLA4 (ROSE-12 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA006163MB15HU	CTLA4 (Tazlestobart Biosimilar) Recombinant Monoclonal Antibody	Human

CTLA4 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA006163ZA01MO	Ctla4 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

CTLA4 Proteins

CTLA4 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP894548DO CSB-EP894548DO CSB-BP894548DO CSB-MP894548DO CSB-EP894548DO-B	Recombinant Dog Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTLA4 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-CF006163RB	Recombinant Rabbit Cytotoxic T-lymphocyte protein 4 (CTLA4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP006163RB1 CSB-EP006163RB1 CSB-BP006163RB1 CSB-MP006163RB1 CSB-EP006163RB1-B	Recombinant Rabbit Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTLA4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP006163HU1 CSB-EP006163HU1 CSB-BP006163HU1 CSB-MP006163HU1 CSB-EP006163HU1-B	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006163HU	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP005231HU	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	Mammalian cell
CSB-EP006163HU1	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	E.coli
CSB-MP006163HU1	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	Mammalian cell
CSB-MP006163HU2l4	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell
CSB-YP006163HU2	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast
CSB-MP006163HU2	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell
CSB-MP006163HU1j1-B	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial,Biotinylated	Mammalian cell
CSB-MP006163HU2d7	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell
CSB-MP006163HU2d9	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell

CTLA4 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP889006PI CSB-EP889006PI CSB-BP889006PI CSB-MP889006PI CSB-EP889006PI-B	Recombinant Pig Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTLA4 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-AP005121GU	Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	Yeast

CTLA4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP006163MO1 CSB-EP006163MO1 CSB-BP006163MO1 CSB-MP006163MO1 CSB-EP006163MO1-B	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006163MO	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006163MO1	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4),Partial	E.coli
CSB-AP005301MO	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	Mammalian cell

CTLA4 ELISA Kit

CTLA4 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E09171h	Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL

CTLA4 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E13637m	Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	0.078 ng/mL

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CTLA4

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