DDR1

Discoid domain receptors (DDRs) are a class of receptor-type tyrosine kinases (RTKs), which can be divided into DDR1 and DDR2, and play an important role in cell adhesion, proliferation and extracellular matrix remodeling. Like other tyrosine protein kinase receptors, DDR1 is autophosphorylated at the ligand binding site. But the difference is that phosphorylation of DDR1 is unusually slow and long-lasting. At present, there are many reports that DDR1 is overexpressed in human tumors such as primary breast cancer, ovarian cancer, and esophageal cancer, and can even reach three times the normal value in childhood brain tumors, and DDR1 mainly exists in highly infiltrating tumor cells. middle. The study also found that overexpression and gain-of-function mutation of DDR1 can increase tumorigenicity in tumor model animals, and knockout of DDR1 gene can inhibit tumorigenesis and metastasis. These pieces of evidence suggest that DDR1 is likely to be a target for anticancer drug development.

More Interesting read related DDR1: DDR1, a Novel Member of the RTKs Family, a Potential Target for Tumor Therapy!

Popular Product

Recombinant Human Epithelial discoidin domain-containing receptor 1(DDR1),partial (Active) (Code: CSB-MP006595HU)

Validated Data

High Purity Validated by SDS-PAGE

The purity was greater than 95% as determined by SDS-PAGE. (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Immobilized Human DDR1 at 2 μg/ml can bind Anti-DDR1 recombinant antibody (CSB-RA006595MA1HU), the EC₅₀ is 2.824-3.810 ng/mL