DLL1

Delta-like protein 1 (DLL1), also known as Delta-1, is a transmembrane protein encoded by the DLL1 gene. It functions as a ligand for Notch receptors, playing a crucial role in cell fate determination, differentiation, and development. DLL1 activates the Notch signaling pathway, which regulates various cellular processes, including proliferation and apoptosis.
Abnormal DLL1 expression is associated with multiple diseases, such as leukemia and solid tumors. Dysregulation of the DLL1-Notch pathway disrupts normal cell behavior and promotes tumor growth. In drug development, targeting the DLL1-Notch interaction is a promising strategy, and several agents are under pre - clinical and clinical evaluation to improve treatment outcomes.