Erythropoietin (EPO) is a secreted glycoprotein primarily produced by interstitial renal tubular fibroblasts in the kidney and hepatocytes and Ito cells in the liver. Belonging to the type I cytokine superfamily, EPO binds to its specific receptor, EPOR, and activates the JAK-STAT signaling pathway. This activation promotes the transformation and maturation of erythroid progenitor cells into red blood cells in the bone marrow, increasing the number of red blood cells and hemoglobin content. EPO is the primary hormone responsible for regulating the proliferation and differentiation of red blood cells, maintaining their circulating levels, and enhancing red blood cell production under hypoxic conditions. Additionally, EPO has protective effects on tissues, safeguarding nerve, cardiovascular, and renal tissues from ischemic and toxic damage.
Popular
Product:
Recombinant Human Erythropoietin (EPO) (Active)(CSB-MP007743HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 0.3534 to 0.7096 ng/mL.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human EPO at 2 μg/mL can bind Anti-EPO recombinant antibody (CSB-RA007743MA1HU).The EC50 is 0.4354-0.5532 ng/mL.
EPO Antibody(CSB-PA06337A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA06337A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA06337A0Rb at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA06337A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following EPO
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
EPO
Antibodies
EPO Antibodies for Equus caballus (Horse)
EPO Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
EPO Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
EPO Antibodies for Homo sapiens (Human)
EPO Antibodies for Sus scrofa (Pig)
EPO Antibodies for Bos taurus (Bovine)
EPO Antibodies for Danio rerio(Zebrafish)(Brachydanio rerio)
EPO Proteins
EPO Proteins for Spalax golani (Golan Heights blind mole rat) (Nannospalax golani)
EPO Proteins for Equus caballus (Horse)
EPO Proteins for Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus)
EPO Proteins for Homo sapiens (Human)
EPO Proteins for Spalax carmeli (Southern Israeli blind subterranean mole rat)
EPO Proteins for Sus scrofa (Pig)
EPO Proteins for Macaca mulatta (Rhesus macaque)
EPO Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
EPO Proteins for Bos taurus (Bovine)
EPO Proteins for Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
EPO Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
EPO Proteins for Ovis aries (Sheep)
EPO Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
EPO Proteins for Felis catus (Cat) (Felis silvestris catus)
EPO Proteins for Oryctolagus cuniculus (Rabbit)
EPO Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
EPO Proteins for Rattus norvegicus (Rat)
EPO Proteins for Spalax judaei (Judean Mountains blind mole rat) (Nannospalax judaei)
EPO Proteins for Bos mutus grunniens (Wild yak) (Bos grunniens)
EPO Proteins for Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili)
EPO Proteins for Danio rerio(Zebrafish)(Brachydanio rerio)
EPO Proteins for Mus musculus (Mouse)
EPO Proteins for Microtus oeconomus (Tundra vole)
