FASLG

FASLG encodes the Fas ligand, also commonly known as CD95 ligand. This protein is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) family. It binds to the Fas receptor, triggering a cascade of events. When FasL binds to Fas, it leads to the activation of caspases, which are responsible for initiating apoptosis. This process is essential in immune regulation and maintaining tissue homeostasis.
Dysregulation of the Fas-FasL interaction is linked to various diseases, such as autoimmune lymphoproliferative syndrome (ALPS). In terms of drug development, agents that target the Fas-FasL pathway are being investigated for potential applications in cancer treatment, aiming to induce apoptosis in tumor cells and enhance the immune response against malignancies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FASLG Antibody(CSB-PA008434LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008434LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008434LA01HU at dilution of 1:100

Immunofluorescence staining of Hela cells with CSB-PA008434LA01HU at 1:330, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Validated Data

Code: CSB-E04544h

Size: ,96T,5×96T,10×96T

Sensitivity: 7.81 pg/mL

Detection Range: 31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following FASLG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FASLG Antibodies

FASLG Proteins

FASLG ELISA Kits

FASLG Antibodies

FASLG Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Species Reactivity	Application
CSB-PA008434ZA01MOV	FASLG Antibody	Macaca fascicularis	ELISA, WB (ensure identification of antigen)

FASLG Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA008434LA01HU	FASLG Antibody	Human	ELISA, IHC, IF
CSB-PA008434LB01HU	FASLG Antibody, HRP conjugated	Human	ELISA
CSB-PA243242	FASLG Antibody	Human	ELISA,WB,IHC
CSB-PA002482	FASLG Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA129637	FASLG Antibody	Human,Mouse,Rat	ELISA,IHC

FASLG Proteins

FASLG Proteins for Macaca nemestrina (Pig-tailed macaque)

Code	Product Name	Source
CSB-CF008434MOX	Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP008434MOX1 CSB-EP008434MOX1 CSB-BP008434MOX1 CSB-MP008434MOX1 CSB-EP008434MOX1-B	Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP771249CA CSB-EP771249CA CSB-BP771249CA CSB-MP771249CA CSB-EP771249CA-B	Recombinant Cat Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-CF008434MOV	Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP008434MOV1 CSB-EP008434MOV1 CSB-BP008434MOV1 CSB-MP008434MOV1 CSB-EP008434MOV1-B	Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF008434MOV2	Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	in vitro E.coli expression system
CSB-EP008434MOV1	Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	E.coli

FASLG Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF008434RA	Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP008434RA1 CSB-EP008434RA1 CSB-BP008434RA1 CSB-MP008434RA1 CSB-EP008434RA1-B	Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP008434HU	Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	E.coli
CSB-EP008434HU(A4)	Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	E.coli
CSB-YP008434HU	Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast
CSB-YP008434HU(A4)	Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast
CSB-YP008434HU CSB-EP008434HU CSB-BP008434HU CSB-MP008434HU CSB-EP008434HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP008434HU(A4) CSB-EP008434HU(A4) CSB-BP008434HU(A4) CSB-MP008434HU(A4) CSB-EP008434HU(A4)-B	Recombinant human Tumor necrosis factor ligand superfamily member 6	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP857726PI CSB-EP857726PI CSB-BP857726PI CSB-MP857726PI CSB-EP857726PI-B	Recombinant Pig Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP008434MOW CSB-EP008434MOW CSB-BP008434MOW CSB-MP008434MOW CSB-EP008434MOW-B	Recombinant Macaca mulatta Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF008434MO	Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP008434MO1 CSB-EP008434MO1 CSB-BP008434MO1 CSB-MP008434MO1 CSB-EP008434MO1-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FASLG Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

Code	Product Name	Source
CSB-YP860198DRI CSB-EP860198DRI CSB-BP860198DRI CSB-MP860198DRI CSB-EP860198DRI-B	Recombinant Cercocebus atys Tumor necrosis factor ligand superfamily member 6 (FASLG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli