FBXW7

FBXW7, also known as F-box and WD repeat domain-containing 7, is a crucial protein in the human body. It has several common aliases such as hCDC4 and SEL-10. This protein functions as a substrate recognition subunit of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex. It tags specific proteins for ubiquitination and subsequent proteasomal degradation.
FBXW7 is involved in multiple signaling pathways including the Notch, Wnt, and mTOR pathways. Aberrations in FBXW7 are linked to various diseases, especially cancer. In terms of drug development, research is actively underway to target FBXW7 as a potential therapeutic strategy, aiming to restore its normal function and regulate related cellular processes.