FGF19

FGF19, also known as fibroblast growth factor 19, is a member of the fibroblast growth factor family. It is also commonly called FGF-19. FGF19 functions by binding to specific FGF receptors, which activates downstream signaling cascades. It is involved in the regulation of bile acid synthesis, glucose and lipid metabolism through the FGFR4/β-Klotho signaling pathway.
Abnormal FGF19 expression is associated with various diseases, including liver diseases, metabolic disorders, and certain cancers. In drug development, FGF19 - related therapies are being explored. Some are aiming to modulate its signaling to treat metabolic and hepatic diseases, showing potential in pre - clinical and early - stage clinical studies.