FGF4

The gene FGF4 encodes the protein Fibroblast Growth Factor 4 (FGF4), also known as HST-1 or HBGF-4. FGF4 is a mitogenic protein that plays critical roles in embryonic development and cell growth. It interacts with FGF receptors (FGFRs) to activate signaling pathways, including the RAS/MAP kinase, PI3/AKT, and PLCγ pathways. Dysregulation of FGF4 is associated with various diseases, such as cancer, where it is often overexpressed. Research into FGF4 has led to the development of potential therapeutic strategies, including FGFR inhibitors for cancer treatment.