HMGCR

HMGCR, full name 3-hydroxy-3-methylglutaryl-CoA reductase. It is a key rate-limiting enzyme in cholesterol synthesis, regulating systemic cholesterol and lipid homeostasis. Abnormal HMGCR overexpression causes hypercholesterolemia and atherosclerosis, and drives tumor progression. HMGCR inhibitors are clinically used for cardiovascular diseases, with new modulators in preclinical research.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HMGCR Antibody(CSB-PA010565LA01HU)

Validated Data

Western Blot
Positive WB detected in: HepG2 whole cell lysate, JK whole cell lysate,PC-3 whole cell lysate,Mouse Brain tissue lysate, Mouse Liver tissue lysate
All lanes: HMGCR antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 98 kDa
Observed band size: 100 kDa

IHC image of CSB-PA010565LA01HU diluted at 1:150 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA010565LA01HU diluted at 1:150 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Hydroxymethylglutaryl CoA Reductase (HMG-CoAR) ELISA kit(CSB-E15964h)

Validated Data

Code: CSB-E15964h

Size: 96T,5×96T,10×96T

Sensitivity: 0.195 ng/mL

Detection Range: 0.78 ng/mL- 50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following HMGCR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

HMGCR Antibodies

HMGCR Proteins

HMGCR ELISA Kits

HMGCR Antibodies

HMGCR Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA010565LD01HU	HMGCR Antibody, Biotin conjugated	Human	ELISA
CSB-PA010565LB01HU	HMGCR Antibody, HRP conjugated	Human	ELISA
CSB-PA010565LA01HU	HMGCR Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA031676	HMGCR Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA929004	HMGCR Antibody	Human,Mouse,Rat	ELISA,IHC

HMGCR Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA010565XA01DLU	Hmgcr Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

HMGCR Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA010565ZA01MO	Hmgcr Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

HMGCR Proteins

HMGCR Proteins for Mesocricetus auratus (Golden hamster)

Code	Product Name	Source
CSB-YP010565MRG CSB-EP010565MRG CSB-BP010565MRG CSB-MP010565MRG CSB-EP010565MRG-B	Recombinant Mesocricetus auratus 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Code	Product Name	Source
CSB-YP010565DXU CSB-EP010565DXU CSB-BP010565DXU CSB-MP010565DXU CSB-EP010565DXU-B	Recombinant Cricetulus griseus 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP010565RA CSB-EP010565RA CSB-BP010565RA CSB-MP010565RA CSB-EP010565RA-B	Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP010565RB CSB-EP010565RB CSB-BP010565RB CSB-MP010565RB CSB-EP010565RB-B	Recombinant Rabbit 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP010565HU	Recombinant Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	E.coli
CSB-YP010565HU CSB-EP010565HU CSB-BP010565HU CSB-MP010565HU CSB-EP010565HU-B	Recombinant Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010565HU2	Recombinant Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	E.coli

HMGCR Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP010565PI CSB-EP010565PI CSB-BP010565PI CSB-MP010565PI CSB-EP010565PI-B	Recombinant Pig 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP010565PYX CSB-EP010565PYX CSB-BP010565PYX CSB-MP010565PYX CSB-EP010565PYX-B	Recombinant Pongo abelii 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Strongylocentrotus purpuratus (Purple sea urchin)

Code	Product Name	Source
CSB-YP010565FOT CSB-EP010565FOT CSB-BP010565FOT CSB-MP010565FOT CSB-EP010565FOT-B	Recombinant Strongylocentrotus purpuratus 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP010565DLU CSB-EP010565DLU CSB-BP010565DLU CSB-MP010565DLU CSB-EP010565DLU-B	Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP010565MO CSB-EP010565MO CSB-BP010565MO CSB-MP010565MO CSB-EP010565MO-B	Recombinant Mouse 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010565MO1	Recombinant Mouse 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial	E.coli

HMGCR Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP010565XBE CSB-EP010565XBE CSB-BP010565XBE CSB-MP010565XBE CSB-EP010565XBE-B	Recombinant Xenopus laevis 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgcr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HMGCR ELISA Kit

HMGCR ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E15964h	Human Hydroxymethylglutaryl CoA Reductase (HMG-CoAR) ELISA kit	serum, plasma, tissue homogenates	0.195 ng/mL

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HMGCR

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