IFNLR1

The protein encoded by IFNLR1 is Interferon lambda receptor 1, also known as IL28Rα. It forms a heterodimer with IL10Rβ to act as the functional receptor for type III interferons (IFN-λs). Ligand binding triggers JAK-STAT pathway activation, driving transcription of antiviral and immune-regulatory genes, critical for innate defense against viral infections.
Dysregulation of IFNLR1 signaling links to chronic HCV infection, COVID-19, and autoimmune disorders like SLE. Drug development includes IFN-λ agonists for viral diseases and antagonists for excessive inflammation, with several candidates in preclinical or early clinical stages, showing potential in modulating immune responses.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IFNLR1 Antibody(CSB-PA816871ESR1HU)

Validated Data

Western Blot
Positive WB detected in A549 whole cell lysate
All lanes: IFNLR1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

IHC image of CSB-PA816871ESR1HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-PA816871ESR1HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of MCF-7 cells with CSB-PA816871ESR1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following IFNLR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IFNLR1 Antibodies

IFNLR1 Proteins

IFNLR1 Antibodies

IFNLR1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA29701A0Rb	ifnlr1 Antibody	Zebrafish	ELISA
CSB-PA29701B0Rb	ifnlr1 Antibody, HRP conjugated	Zebrafish	ELISA
CSB-PA29701C0Rb	ifnlr1 Antibody, FITC conjugated	Zebrafish
CSB-PA29701D0Rb	ifnlr1 Antibody, Biotin conjugated	Zebrafish	ELISA

IFNLR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA004734	IFNLR1 Antibody	Human	WB, ELISA
CSB-PA816871ESR1HU	IFNLR1 Antibody	Human	ELISA, WB, IHC, IF
CSB-MA816871A0m	IFNLR1 Monoclonal Antibody	Human	ELISA, IF

IFNLR1 Proteins

IFNLR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP816871HU1 CSB-EP816871HU1 CSB-BP816871HU1 CSB-MP816871HU1 CSB-EP816871HU1-B	Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP816871HU1	Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial	E.coli
CSB-EP816871HU1a2	Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial	E.coli
CSB-EP816871HU1a0	Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial	E.coli

IFNLR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP806069MO CSB-EP806069MO CSB-BP806069MO CSB-MP806069MO CSB-EP806069MO-B	Recombinant Mouse Interleukin-28 receptor subunit alpha (Il28ra), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily?Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

IFNLR1

Popular Product: