IL13

IL13, interleukin-13 (Interleukin-13), is a cytokine produced by Th2-type helper T cells. It plays a key role in the regulation of immune responses, particularly in allergic reactions and antiparasitic immunity.IL13 activates the JAK-STAT signalling pathway by binding to its specific receptors, IL13Rα1 and IL4Rα chains, which in turn affects the gene expression of a variety of cell types, including B cells, macrophages and epithelial cells. This signalling leads to immune cell activation, proliferation and differentiation, while promoting antibody production and the regulation of inflammatory responses.IL13 is involved in a variety of physiological and pathological processes, including the development of allergic diseases such as asthma and atopic dermatitis, and immune responses against parasitic infections. In addition, IL13 may play a role in the regulation of the tumour microenvironment and in autoimmune diseases, making it an important molecule for immunological research and the development of therapeutic strategies.