IL18R1

The gene IL18R1 encodes the protein Interleukin 18 Receptor 1, also known as IL-18R. This receptor is crucial for the signaling of interleukin-18 (IL-18), a pro-inflammatory cytokine. IL-18R1 interacts with IL-18 to activate downstream signaling pathways, including those involving STAT4, NFkB, and MAPK, leading to the production of IFN-γ and other inflammatory mediators. The IL-18R1/IL-18 axis is involved in various immune responses and plays a role in several inflammatory and autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Research into IL-18R1 has led to the development of monoclonal antibodies and other drugs targeting this receptor, offering potential therapeutic strategies for these conditions.