INSR

INSR corresponds to the Insulin Receptor protein. It is also commonly known as CD220. This protein plays a crucial role in regulating glucose metabolism. Upon binding with insulin, it activates tyrosine kinase activity, triggering a cascade of phosphorylation events. This process is involved in the PI3K - AKT and MAPK signaling pathways.
Dysfunction of INSR is associated with various diseases such as type 2 diabetes and insulin resistance. In drug development, efforts are focused on designing agonists or modulators to enhance insulin - receptor function, aiming to improve glycemic control and treat associated metabolic disorders.