LTA

Lymphotoxin-alpha (LTA), encoded by the LTA gene, is a member of the tumor necrosis factor (TNF) superfamily, also known as TNF-beta. It forms homotrimers or heterotrimers with lymphotoxin-beta to bind TNF receptors (TNFR1/2), activating NF-κB and MAPK signaling pathways. These cascades regulate immune cell activation, lymphoid organ development, and inflammatory responses.
Aberrant LTA signaling links to autoimmune disorders (e.g., rheumatoid arthritis, multiple sclerosis) and lymphoproliferative diseases. Drug development includes monoclonal antibodies targeting LTA or its receptors; preclinical candidates show promise in reducing inflammation, while early clinical trials evaluate their safety and efficacy for autoimmune conditions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B (CSB-MP023978HU2), the EC₅₀ is 1.632-2.699 ng/ml.

Activity
Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1(CSB-MP023977HU1), the EC₅₀ of human LTA protein is 4.409-6.797 ng/ml.

LTA Antibody(CSB-PA863040)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA863040(LTA Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA863040(LTA Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Human Tumor necrosis factor β,TNF-β ELISA KIT(CSB-E04743h)

Validated Data

Code: CSB-E04743h

Size: 96T,5×96T,10×96T

Sensitivity: 3.9 pg/mL

Detection Range: 15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following LTA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

LTA Antibodies

LTA Proteins

LTA ELISA Kits

LTA Antibodies

LTA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA013218KA01HU	LTA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA004313	LTA Antibody	Human,Mouse,Rat,Monkey	WB, ELISA
CSB-PA863040	LTA Antibody	Human	ELISA,IHC
CSB-RA013218A0HU	LTA Recombinant Monoclonal Antibody	Human	ELISA

LTA Antibodies for Zebrafish

Code	Product Name	Species Reactivity	Application
CSB-PA24269A0Rb	lta Antibody	Zebrafish	ELISA, WB
CSB-PA24269C0Rb	lta Antibody, FITC conjugated	Zebrafish
CSB-PA24269D0Rb	lta Antibody, Biotin conjugated	Zebrafish	ELISA

LTA Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA013218ZA01MO	Lta Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

LTA Proteins

LTA Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP013218EQV CSB-EP013218EQV CSB-BP013218EQV CSB-MP013218EQV CSB-EP013218EQV-B	Recombinant Pan troglodytes Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP730213DO CSB-EP730213DO CSB-BP730213DO CSB-MP730213DO CSB-EP730213DO-B	Recombinant Dog Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP013218HU CSB-EP013218HU CSB-BP013218HU CSB-MP013218HU CSB-EP013218HU-B	Recombinant Human Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP002171HU	Recombinant Human Lymphotoxin-alpha protein (LTA) (Active)	E.coli
CSB-AP004941HU	Recombinant Human Lymphotoxin-alpha (LTA) (Active)	E.coli
CSB-MP013218HU	Recombinant Human Lymphotoxin-alpha (LTA) (Active)	Mammalian cell
CSB-MP013218HU-B	Recombinant Human Lymphotoxin-alpha (LTA), partial,Biotinylated	Mammalian cell

LTA Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP013218RB CSB-EP013218RB CSB-BP013218RB CSB-MP013218RB CSB-EP013218RB-B	Recombinant Rabbit Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP013218PI CSB-EP013218PI CSB-BP013218PI CSB-MP013218PI CSB-EP013218PI-B	Recombinant Pig Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP713142MOW CSB-EP713142MOW CSB-BP713142MOW CSB-MP713142MOW CSB-EP713142MOW-B	Recombinant Macaca mulatta Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Macropus eugenii (Tammar wallaby) (Notamacropus eugenii)

Code	Product Name	Source
CSB-YP894074MPE CSB-EP894074MPE CSB-BP894074MPE CSB-MP894074MPE CSB-EP894074MPE-B	Recombinant Macropus eugenii Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Marmota monax (Woodchuck)

Code	Product Name	Source
CSB-YP862417MQG CSB-EP862417MQG CSB-BP862417MQG CSB-MP862417MQG CSB-EP862417MQG-B	Recombinant Marmota monax Lymphotoxin-alpha (LTA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LTA Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP013218MO CSB-EP013218MO CSB-BP013218MO CSB-MP013218MO CSB-EP013218MO-B	Recombinant Mouse Lymphotoxin-alpha (Lta)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP013218MO	Recombinant Mouse Lymphotoxin-alpha (Lta)	E.coli
CSB-EP013218MOa0	Recombinant Mouse Lymphotoxin-alpha (Lta)	E.coli