MAP3K1

MAP3K1, also known as mitogen-activated protein kinase kinase 1, has alternative names including MEKK1, MEKK, MEKK 1, and SRXY6. MAP3K1 plays a role in various cellular signaling pathways, particularly in the MAPK signaling pathway. MAP3K1 can activate downstream MAP2Ks and MAPKs, transmitting signals through a series of phosphorylation steps to regulate multiple functions such as apoptosis, survival, migration, and differentiation. MAP3K1 is also involved in the ubiquitin-proteasome system, exhibiting E3 ubiquitin ligase activity that promotes the ubiquitination and degradation of specific proteins.
Abnormalities in MAP3K1 function are associated with the development and progression of various cancers, including breast cancer and ovarian cancer, making it a potential target for cancer control.