PDGFRB

PDGFRB encodes the Platelet - derived growth factor receptor beta. It is also commonly known as PDGF - betaR. This protein plays a crucial role in cell proliferation, survival, and migration. It acts by binding to platelet - derived growth factors, leading to autophosphorylation and activation of downstream signaling pathways, such as the PI3K/Akt and MAPK/ERK pathways.
Aberrant activation of PDGFRB is associated with various diseases, including certain types of leukemia and solid tumors. In drug development, several small - molecule inhibitors targeting PDGFRB have been investigated. Some have shown promise in pre - clinical and clinical trials, aiming to block its activity and treat related diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PDGFRB at 2 μg/ml can bind Anti-PDGFRB recombinant antibody (CSB-RA017713MA1HU). The EC₅₀ is 2.471-2.776 ng/mL.

The purity of PDGFRB was greater than 95% as determined by SEC-HPLC

Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial(CSB-EP017713HU)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDGFRB Recombinant Monoclonal Antibody(CSB-RA213932A0HU)

Validated Data

IHC image of CSB-RA213932A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following PDGFRB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PDGFRB Antibodies

PDGFRB Proteins

PDGFRB ELISA Kits

PDGFRB Antibodies

PDGFRB Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA017713GA01HU	PDGFRB Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA828739	PDGFRB (Ab-751) Antibody	Human,Rat	ELISA,WB
CSB-PA979025	Phospho-PDGFRB (Tyr740) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA556830	PDGFRB (Ab-771) Antibody	Human,Rat	ELISA,WB
CSB-PA000745	Phospho-PDGFRB (Y1021) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA003726	PDGFRB Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA004625	PDGFRB Antibody	Human,Rat	WB, ELISA
CSB-PA030005	Phospho-PDGFRB (Y771) Antibody	Human,Rat	WB, ELISA
CSB-PA030006	Phospho-PDGFRB (Y740) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA030007	Phospho-PDGFRB (Y751) Antibody	Human,Mouse,Rat	IHC, IF, ELISA
CSB-PA030008	PDGFRB Antibody	Human,Mouse,Rat	IHC, IF, ELISA
CSB-PA030009	PDGFRB Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA030010	PDGFRB Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA208206	PDGFRB Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA266610	PDGFRB Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA017713LA01HU	PDGFRB Antibody	Human	ELISA, IHC, IF
CSB-PA017713LD01HU	PDGFRB Antibody, Biotin conjugated	Human	ELISA
CSB-PA017713LC01HU	PDGFRB Antibody, FITC conjugated	Human
CSB-PA017713LB01HU	PDGFRB Antibody, HRP conjugated	Human	ELISA
CSB-RA017713A740phHU	Phospho-PDGFRB (Y740) Recombinant Monoclonal Antibody	Human	ELISA, WB
CSB-RA213932A0HU	PDGFRB Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA017713MB1HU	PDGFRB (rinucumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA017713MA1HU	PDGFRB Recombinant Monoclonal Antibody	Human	ELISA, IHC

PDGFRB Proteins

PDGFRB Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP764838DO CSB-EP764838DO CSB-BP764838DO CSB-MP764838DO CSB-EP764838DO-B	Recombinant Dog Platelet-derived growth factor receptor beta (PDGFRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDGFRB Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP017713HU CSB-EP017713HU CSB-BP017713HU CSB-MP017713HU CSB-EP017713HU-B	Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017713HU	Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial	E.coli
CSB-MP017713HU1	Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial (Active)	Mammalian cell

PDGFRB Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Code	Product Name	Source
CSB-YP304446TKY CSB-EP304446TKY CSB-BP304446TKY CSB-MP304446TKY CSB-EP304446TKY-B	Recombinant Takifugu rubripes Platelet-derived growth factor receptor beta (pdgfrb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDGFRB Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP017713MO CSB-EP017713MO CSB-BP017713MO CSB-MP017713MO CSB-EP017713MO-B	Recombinant Mouse Platelet-derived growth factor receptor beta (Pdgfrb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDGFRB ELISA Kit

PDGFRB ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL017713HU	Human Beta-type platelet-derived growth factor receptor(PDGFRB) ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL

PDGFRB ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-EL017713MO	Mouse Beta-type platelet-derived growth factor receptor(PDGFRB) ELISA kit	serum, plasma, tissue homogenates, cell lysates	0.31 ng/ml

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PDGFRB

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