PPP6C

PPP6C, also known as Protein Phosphatase 6 Catalytic Subunit, is a serine/threonine phosphatase that plays a crucial role in cell cycle regulation, DNA damage response, and cell size control. It functions as a negative regulator of the G1 to S phase progression by dephosphorylating key proteins involved in these processes. PPP6C is a component of the PP6 protein complex, which includes regulatory subunits and ankyrin repeat domain-containing proteins. Dysregulation of PPP6C has been associated with various diseases, including melanoma and lung squamous cell carcinoma. Research into PPP6C has identified its involvement in the MAPK and NF-κB signaling pathways, where it negatively regulates these pathways by dephosphorylating key kinases and substrates. The study of PPP6C mutations and their impact on these pathways has led to potential therapeutic targets for cancer treatment.