PTPN1

PTPN1, also known as PTP1B, is a protein encoded by the PTPN1 gene and belongs to the protein tyrosine phosphatase family, with expression in a range of tissues. It modulates various signaling pathways by dephosphorylating tyrosine residues on proteins, including those in the insulin and immune cell receptor signaling pathways. PTPN1's influence on cell growth, differentiation, migration, apoptosis, and metabolism is substantial. Its dysfunction is implicated in a spectrum of diseases such as diabetes, obesity, cancer, and autoimmune conditions, marking it as a key molecular target in cellular and disease research.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PTPN1 Recombinant Monoclonal Antibody(CSB-RA272100A0HU)

Validated Data

Western Blot
Positive WB detected in: PC-3 whole cell lysate, THP-1 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, U87 whole cell lysate
All lanes: PTPN1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa

IHC image of CSB-RA272100A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA272100A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following PTPN1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PTPN1 Antibodies

PTPN1 Proteins

PTPN1 Antibodies

PTPN1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA019024GA01HU	PTPN1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA019024DSR1HU	PTPN1 Antibody	Human	ELISA, WB
CSB-PA129081	Phospho-PTPN1 (Ser50) Antibody	Human,Mouse,Rat,Monkey	ELISA,WB
CSB-PA003883	PTPN1 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA040100	Phospho-PTPN1 (S50) Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-RA272100A0HU	PTPN1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

PTPN1 Proteins

PTPN1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP019024CH CSB-EP019024CH CSB-BP019024CH CSB-MP019024CH CSB-EP019024CH-B	Recombinant Chicken Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTPN1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP019024HU CSB-EP019024HU CSB-BP019024HU CSB-MP019024HU CSB-EP019024HU-B	Recombinant Human Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP019024HU1	Recombinant Human Tyrosine-protein phosphatase non-receptor type 1 (PTPN1), partial	E.coli

PTPN1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP019024RA CSB-EP019024RA CSB-BP019024RA CSB-MP019024RA CSB-EP019024RA-B	Recombinant Rat Tyrosine-protein phosphatase non-receptor type 1 (Ptpn1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTPN1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP019024MO CSB-EP019024MO CSB-BP019024MO CSB-MP019024MO CSB-EP019024MO-B	Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 1 (Ptpn1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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PTPN1

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