RAC1

RAC1, identified as the ras-associated C3 botulinum toxin substrate 1, is a small GTPase widely expressed across various cell types. It plays a pivotal role in intracellular signal transduction, promoting cytoskeletal rearrangements and cell movement upon GTP binding. RAC1's activation is particularly crucial for the regulation of actin filament dynamics, impacting cell migration, proliferation, differentiation, phagocytosis, and signaling. Its influence extends to immune cell function, tumor cell invasion and metastasis, and nerve cell development, with dysregulation linked to diseases like inflammation and cancer.