SIRPB1

SIRPB1, short for Signal Regulatory Protein Beta 1, also known by aliases such as CD172b. This protein plays a crucial role in immune - related processes. It functions by interacting with ligands on other cells, modulating cell - cell communication. It is involved in the SIRP - CD47 signaling pathway, which regulates phagocytosis and immune cell activation.
Dysregulation of SIRPB1 has been associated with various diseases, including certain types of cancers where abnormal signaling may promote tumor immune evasion. In drug development, researchers are exploring agents that target SIRPB1 or its related pathways to enhance anti - tumor immune responses, though significant progress is still needed.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRPB1 Antibody(CSB-PA021335LA01HU)

Validated Data

Immunofluorescence staining of U251 cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of U251 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Western Blot
Positive WB detected in: THP-1 whole cell lysate(20µg), U87 whole cell lysate(20µg), A549 whole cell lysate(20µg), PC-3 whole cell lysate(20µg)
All lanes: SIRPB1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 43,19 kDa
Observed band size: 43,86 kDa
Exposure time: 120s

Immunofluorescence staining of Hela cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following SIRPB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SIRPB1 Antibodies

SIRPB1 Proteins

SIRPB1 Antibodies

SIRPB1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA021335GA01HU	SIRPB1 Antibody	Human	ELISA,WB,IHC
CSB-PA988979	SIRPB1 Antibody	Human	ELISA,WB
CSB-PA001428	SIRPB1 Antibody	Human	WB, ELISA
CSB-PA006284	SIRPA/SIRPB1 Antibody	Human	WB, ELISA
CSB-PA021335LA01HU	SIRPB1 Antibody	Human	ELISA, WB, IF
CSB-PA021335LB01HU	SIRPB1 Antibody, HRP conjugated	Human	ELISA
CSB-PA021335LC01HU	SIRPB1 Antibody, FITC conjugated	Human
CSB-PA021335LD01HU	SIRPB1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA732939LA01HU	SIRPB1 Antibody	Human	ELISA, IHC, IF
CSB-PA732939LB01HU	SIRPB1 Antibody, HRP conjugated	Human	ELISA
CSB-PA732939LC01HU	SIRPB1 Antibody, FITC conjugated	Human
CSB-PA732939LD01HU	SIRPB1 Antibody, Biotin conjugated	Human	ELISA

SIRPB1 Proteins

SIRPB1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP021335HU	Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial	Yeast
CSB-YP732939HU CSB-EP732939HU CSB-BP732939HU CSB-MP732939HU CSB-EP732939HU-B	Recombinant Human Signal-regulatory protein beta-1 isoform 3 (SIRPB1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP021335HU	Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial	Mammalian cell
CSB-EP021335HU	Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial	E.coli
CSB-YP021335HU CSB-EP021335HU CSB-BP021335HU CSB-MP021335HU CSB-EP021335HU-B	Recombinant Human Signal-regulatory protein beta-1 (SIRPB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP021335HUd7	Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (Active)	Mammalian cell

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SIRPB1

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