SOCS3

SOCS3, Suppressor of cytokine signaling 3, alias EF10, EF-10, CISH3, SSI3, CIS-3, SOCS-3, ATOD4, MGC71791, etc. SOCS3 is encoded by the human SOCS3 gene, which is widely expressed in a wide range of tissues. SOCS3 negatively regulates cytokine signaling mainly by binding to tyrosine kinase receptors in the JAK/STAT signaling pathway and inhibiting their activity. It can inhibit a variety of cytokine signaling including gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptor.
SOCS3 is involved in the regulation of immune responses, inflammatory processes, and metabolic processes, and plays an important role in the maintenance of the body's immune homeostasis and the inhibition of tumor growth. Abnormal expression of SOCS3 has been associated with a wide range of diseases, including tumors, autoimmune diseases and metabolic diseases.