SPOP

Speckle-type POZ protein is a protein in humans that is encoded by SPOP gene. Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.

The following SPOP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SPOP Antibodies

SPOP Proteins

SPOP Antibodies

SPOP Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA022601XA01DIL	spop Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

SPOP Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA022601LA01HU	SPOP Antibody	Human	ELISA, IHC
CSB-PA022601LD01HU	SPOP Antibody, Biotin conjugated	Human	ELISA
CSB-PA022601LC01HU	SPOP Antibody, FITC conjugated	Human

SPOP Proteins

SPOP Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP022601DIL CSB-EP022601DIL CSB-BP022601DIL CSB-MP022601DIL CSB-EP022601DIL-B	Recombinant Danio rerio Speckle-type POZ protein (spop)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPOP Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP022601HU CSB-EP022601HU CSB-BP022601HU CSB-MP022601HU CSB-EP022601HU-B	Recombinant Human Speckle-type POZ protein (SPOP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPOP Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP022601PYX CSB-EP022601PYX CSB-BP022601PYX CSB-MP022601PYX CSB-EP022601PYX-B	Recombinant Pongo abelii Speckle-type POZ protein (SPOP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPOP Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP022601BO CSB-EP022601BO CSB-BP022601BO CSB-MP022601BO CSB-EP022601BO-B	Recombinant Bovine Speckle-type POZ protein (SPOP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPOP Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP022601XBF CSB-EP022601XBF CSB-BP022601XBF CSB-MP022601XBF CSB-EP022601XBF-B	Recombinant Xenopus tropicalis Speckle-type POZ protein (spop)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPOP Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP022601MO CSB-EP022601MO CSB-BP022601MO CSB-MP022601MO CSB-EP022601MO-B	Recombinant Mouse Speckle-type POZ protein (Spop)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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