SUCNR1

SUCNR1, or Succinate Receptor 1 (common alias GPR91), is a G-protein coupled receptor (GPCR) that functions as an extracellular succinate sensor. Succinate—a key tricarboxylic acid (TCA) cycle metabolite—accumulates outside cells during metabolic stress or hypoxia; SUCNR1 mediates downstream responses in tissues like the kidney, liver, and immune cells.
Activation of SUCNR1 triggers Gq/11 and Gi/o signaling pathways, leading to calcium mobilization, MAPK activation, and pro-inflammatory cytokine release. It is linked to renal ischemia-reperfusion injury, renal cell carcinoma, type 2 diabetes, and inflammatory disorders. Preclinical studies are exploring SUCNR1 antagonists as potential therapies, though no drugs have advanced to clinical trials yet.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SUCNR1 Antibody(CSB-PA022921LA01HU)

Validated Data

Western blot
All lanes: SUCNR1 antibody at 6µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39 kDa
Observed band size: 39 kDa

Immunofluorescent analysis of Hela cells using CSB-PA022921LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA022921LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022921LA01HU at dilution of 1:100

The following SUCNR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SUCNR1 Antibodies

SUCNR1 Proteins

SUCNR1 Antibodies

SUCNR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA040022	SUCNR1 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-PA022921LA01HU	SUCNR1 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA022921LB01HU	SUCNR1 Antibody, HRP conjugated	Human	ELISA
CSB-PA022921LC01HU	SUCNR1 Antibody, FITC conjugated	Human
CSB-PA022921LD01HU	SUCNR1 Antibody, Biotin conjugated	Human	ELISA

SUCNR1 Proteins

SUCNR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF022921HU	Recombinant Human Succinate receptor 1 (SUCNR1)	in vitro E.coli expression system
CSB-YP022921HU1 CSB-EP022921HU1 CSB-BP022921HU1 CSB-MP022921HU1 CSB-EP022921HU1-B	Recombinant Human Succinate receptor 1 (SUCNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP022921HU	Recombinant Human Succinate receptor 1 (SUCNR1)-VLPs	Mammalian cell

SUCNR1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF022921RA	Recombinant Rat Succinate receptor 1 (Sucnr1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP022921RA1 CSB-EP022921RA1 CSB-BP022921RA1 CSB-MP022921RA1 CSB-EP022921RA1-B	Recombinant Rat Succinate receptor 1 (Sucnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SUCNR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF022921MO	Recombinant Mouse Succinate receptor 1 (Sucnr1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP022921MO1 CSB-EP022921MO1 CSB-BP022921MO1 CSB-MP022921MO1 CSB-EP022921MO1-B	Recombinant Mouse Succinate receptor 1 (Sucnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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SUCNR1

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