TNFRSF11B

TNFRSF11B, a member of the tumor necrosis factor receptor superfamily, is a glycoprotein that predominantly regulates bone metabolism and prevents bone resorption. Residing on chromosome 8q24, the TNFRSF11B gene is composed of five introns and five exons, encoding a precursor of 401 amino acids that matures into a 380 amino acid protein. This protein, made up of seven segments (D1–D7), binds to RANKL within the D1–D4 domains to inhibit osteoclast formation. Expressed abundantly in various tumors, TNFRSF11B is implicated in tumorigenesis and may protect tumor cells from apoptosis while promoting their proliferation and metastasis by binding to TRAIL. As a result, TNFRSF11B holds potential as a novel biomarker and therapeutic target in cancer treatment.