TNFSF11

TNFSF11, a member of the tumor necrosis factor superfamily 11, is a crucial cytokine for bone metabolism, immune system function, and tumor biology. Produced by T cells, it activates the NF-κB signaling pathway by binding to its receptor RANK, promoting osteoclast differentiation and activity, and affecting bone resorption. Abnormal TNFSF11 expression is related to osteoporosis, bone metastatic cancer, and may promote tumor cell invasion and metastasis in the tumor microenvironment.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF11 at 2 μg/ml can bind Human TNFRSF11B (CSB-MP023969HU). The EC₅₀ is 4.514-5.152 ng/mL.

TNFSF11 Antibody(CSB-PA023986LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA023986LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023986LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA023986LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following TNFSF11 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TNFSF11 Antibodies

TNFSF11 Proteins

TNFSF11 ELISA Kits

TNFSF11 Antibodies

TNFSF11 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA111246	TNFSF11 Antibody	Human,Mouse	ELISA,WB,IF
CSB-PA003937	TNFSF11 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-PA005647	TNFSF11 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA023986LA01HU	TNFSF11 Antibody	Human	ELISA, IHC, IF
CSB-PA023986LB01HU	TNFSF11 Antibody, HRP conjugated	Human	ELISA
CSB-PA023986LC01HU	TNFSF11 Antibody, FITC conjugated	Human
CSB-PA023986LD01HU	TNFSF11 Antibody, Biotin conjugated	Human	ELISA
CSB-RA023986MB1HU	TNFSF11 (Denosumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB2HU	TNFSF11 (Denosumab-BBDZ Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB3HU	TNFSF11 (Denosumab-bmwo Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB4HU	TNFSF11 (Denosumab-bnht Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB5HU	TNFSF11 (Denosumab-dssb Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB6HU	TNFSF11 (GB-223 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB7HU	TNFSF11 (LZM-004 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB8HU	TNFSF11 (Narlumosbart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB9HU	TNFSF11 (MV-088 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB10HU	TNFSF11 (G201702 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB11HU	TNFSF11 (HS629 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA023986MB12HU	TNFSF11 (HL05 Biosimilar) Recombinant Monoclonal Antibody	Human

TNFSF11 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA07964A0Rb	Tnfsf11 Antibody	Mouse	ELISA
CSB-PA07964C0Rb	Tnfsf11 Antibody, FITC conjugated	Mouse
CSB-PA07964D0Rb	Tnfsf11 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA023986LA01MO	Tnfsf11 Antibody	Mouse	ELISA, IF
CSB-PA023986LB01MO	Tnfsf11 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA023986LC01MO	Tnfsf11 Antibody, FITC conjugated	Mouse
CSB-PA023986LD01MO	Tnfsf11 Antibody, Biotin conjugated	Mouse	ELISA
CSB-EAP07964	Tnfsf11 Antibody Pair	Human,Mouse,Guinea pig,Pig,Dog	S-ELISA

TNFSF11 Proteins

TNFSF11 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP880653RA CSB-EP880653RA CSB-BP880653RA CSB-MP880653RA CSB-EP880653RA-B	Recombinant Rat Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFSF11 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP023986HU1 CSB-EP023986HU1 CSB-BP023986HU1 CSB-MP023986HU1 CSB-EP023986HU1-B	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023986HU	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP004851HU	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	E.coli
CSB-MP023986HU(F2)	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	Mammalian cell
CSB-MP023986HU(F2)b0	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial	Mammalian cell
CSB-MP023986HU1(F2)	Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	Mammalian cell

TNFSF11 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP023986MO CSB-EP023986MO CSB-BP023986MO CSB-MP023986MO CSB-EP023986MO-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023986MO	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial	E.coli
CSB-CF023986MO(A4)	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP005021MO	Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial (Active)	Mammalian cell

TNFSF11 ELISA Kit

TNFSF11 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E05126r	Rat soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	serum, plasma, cell culture supernates	0.039 ng/mL

TNFSF11 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E05125h	Human soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	serum, plasma, cell culture supeernates, tissue homogenates	1.95 pg/mL

TNFSF11 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E05127m	Mouse soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	serum, plasma, tissue homogenates.	3.12 pg/ml.

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TNFSF11

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