TTN

The protein encoded by TTN is titin (alias connectin), the largest human protein. It acts as a structural scaffold in sarcomeres, linking Z-discs to M-lines to maintain myofibril integrity. Titin also provides passive elasticity during muscle contraction, supporting mechanical stability of skeletal and cardiac muscles.
TTN mutations are linked to dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and skeletal myopathies. Relevant pathways include muscle development and cytoskeletal regulation. Current treatments are symptomatic (β-blockers, ACE inhibitors), while gene therapies like antisense oligonucleotides targeting abnormal splicing are in early preclinical research.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TTN Recombinant Monoclonal Antibody(CSB-RA025267MA1HU)

Validated Data

IHC image of CSB-RA025267MA1HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA025267MA1HU diluted at 1:50 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

Human Titin(TTN) ELISA kit(CSB-EL025267HU)

Validated Data

Code: CSB-EL025267HU

Size: 96T,5×96T,10×96T

Sensitivity: 5.8 pg/mL

Detection Range: 23.5 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following TTN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TTN Antibodies

TTN Proteins

TTN ELISA Kits

TTN Antibodies

TTN Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA15079A0Rb	TTN Antibody	Human	ELISA, IHC, IF
CSB-RA025267MA1HU	TTN Recombinant Monoclonal Antibody	Human	ELISA, IHC

TTN Proteins

TTN Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP025267HU CSB-EP025267HU CSB-BP025267HU CSB-MP025267HU CSB-EP025267HU-B	Recombinant Human Titin (TTN), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP025267HU	Recombinant Human Titin (TTN), partial	E.coli
CSB-EP025267HU1(F6)	Recombinant Human Titin (TTN), partial	E.coli
CSB-EP025267HUc7	Recombinant Human Titin (TTN), partial	E.coli
CSB-EP025267HU2	Recombinant Human Titin (TTN), partial	E.coli
CSB-YP025267HU2	Recombinant Human Titin (TTN),partial	Yeast
CSB-MP025267HU2	Recombinant Human Titin (TTN), partial	Mammalian cell

TTN Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP025267MO CSB-EP025267MO CSB-BP025267MO CSB-MP025267MO CSB-EP025267MO-B	Recombinant Mouse Titin (Ttn), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP025267MO	Recombinant Mouse Titin (Ttn), partial	E.coli

TTN ELISA Kit

TTN ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL025267HU	Human Titin(TTN) ELISA kit	serum, plasma, tissue homogenates, cell lysates	5.8 pg/mL

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TTN

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