UBR5

UBR5, also known as ubiquitin protein ligase E3 component n-recognizing protein 5, has alternative names including DD5, EDD, HYD, and EDD1. UBR5 belongs to the HECT family of E3 ubiquitin protein ligases and possesses an HECT domain, enabling it to modify proteins by adding ubiquitin. UBR5 can recognize specific N-terminal degradation signals of proteins and promote their ubiquitination and subsequent degradation.
UBR5 is involved in the regulation of DNA damage response, metabolism, transcription, and apoptosis, serving as a key regulator of the ubiquitin-proteasome system (UPS) during cancer and development. Abnormal expression or mutations in UBR5 can lead to abnormal accumulation or degradation of proteins within cells, affecting normal cellular function and physiological balance. This provides favorable conditions for tumor proliferation, transcriptional regulation, and immune evasion, ultimately promoting the development of tumors.