YAP1

YAP1, yes-associated protein 1, alias Yes1 Associated Transcriptional Regulator, YAP652, YAP-12, Yes-Associated Protein YAP65 Homolog, Transcriptional Coactivator YAP1, Yes Associated Protein 123, Protein Yorkie Homolog, Yes-Associated Protein 1, 65kDa, etc . It is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway and plays an important role in normal tissue homeostasis and regeneration, as well as in cancer development, invasion, metastasis, and resistance to therapy.The mechanism of action of YAP1 is mainly to affect cell proliferation and apoptosis by correlating with kinase cascades in the Hippo signaling pathway. When the Hippo signaling pathway is activated, YAP1 is phosphorylated by LATS1/2 kinases, leading to its segregation in the cytoplasm and proteasomal degradation. And when the Hippo signaling pathway is turned off, YAP1 is dephosphorylated and translocated to the nucleus, where it binds to transcription factors, such as members of the TEAD family, and activates the expression of downstream genes, thereby regulating cell growth, metabolism, proliferation, migration, invasion, or death . In addition, YAP1 is also involved in the regulation of tissue tension and 3D tissue morphology, and plays a role in regulating the formation of cortical actin networks.

YAP1 has a wide range of biological significance, which is not only involved in the regulation of tissue growth and organ size, but is also closely related to the development of a variety of diseases.Abnormal expression or dysfunction of YAP1 has been associated with tumorigenesis, invasiveness, metastasis, and resistance to treatment. that is a potential target in cancer therapy. In addition, YAP1 is involved in the regulation of important biological processes such as immune response, cell contact response, cell proliferation and apoptosis.