ZAP70

ZAP70, ζ chain-associated kinase 70, is a protein encoded by human gene expression and belongs to the tyrosine kinase family. Expressed in T cells and NK cells, ZAP70 is intricately involved in the T cell receptor (TCR) signaling pathway. It activates immune responses in T and NK cells through its tyrosine kinase activity. The normal function of ZAP70 is indispensable for proper T cell development and immune response. Moreover, aberrant ZAP70 expression is closely tied to poor prognoses in diseases like chronic lymphocytic leukemia (CLL), offering valuable insights for clinical diagnosis and treatment.