AMOTL1 Antibody

Code: CSB-PA812894XA01HU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Homo sapiens (Human)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q8IY63

Target Names

AMOTL1

Alternative Names

2310010G08Rik antibody; 2310067L22Rik antibody; 4932416D09Rik antibody; AMOL1_HUMAN antibody; Amotl1 antibody; Angiomotin-like protein 1 antibody; FLJ00155 antibody; JEAP antibody; Junction enriched and associated protein antibody; mFLJ00155 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) AMOTL1 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.

Gene References into Functions

AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. PMID:26806348
phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. PMID:25373897
miR-124 binds AmotL1 3'UTR and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells. PMID:25218344
These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs. PMID:23793505
AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. PMID:21685940
By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein of parainfluenza virus 5 (PIV5). PMID:19932912