Ifih1 Antibody

1. findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2 PMID:29032202
2. These findings imply that MDA5-induced cell death and inflammation in the pancreas facilitate progression to autoimmune destruction of pancreatic beta-cells. PMID:28851763
3. Mice with a knock-in mutation encoding IFIH1(T946) displayed enhanced basal expression of type I interferons, survived a lethal viral challenge and exhibited increased penetrance in autoimmune models, including a combinatorial effect with other risk variants. Furthermore, IFIH1(T946) mice manifested an embryonic survival defect consistent with enhanced responsiveness to RNA self ligands. PMID:28553952
4. TRIM65 as an essential component for the MDA5 signaling pathway and provide physiological evidence showing that ubiquitination is important for MDA5 oligomerization and activation. PMID:28031478
5. MDA-5 stimulation leads to endothelial dysfunction. PMID:27130701
6. The p150 isoform of ADAR1 uniquely regulated the MDA5 pathway. PMID:26588779
7. MDA5, detects viral RNA and triggers induction of type I interferons, chemical messengers that induce inflammation and help regulate the immune responses. PMID:26423942
8. Duox2-derived reactive oxygen species are necessary for the innate immune response and trigger the induction of RIG-I and MDA5 to resist influenza A infection in human nasal epithelium and mouse nasal mucosa. PMID:25751630
9. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 in virally-infected cells. PMID:24550253
10. embryonic death and phenotypes of Adar1(E861A/E861A) were rescued by concurrent deletion of the cytosolic sensor of dsRNA, MDA5. PMID:26275108
11. IFIH1 heterozygous mice have a regulatory rather than effector T-cell response at the site of autoimmunity, supporting IFIH1 expression as an essential regulator of the diabetogenic T-cell response. PMID:25591872
12. Our results, therefore, suggest that Arl5B is a negative regulator for MDA5. PMID:25451939
13. TRIM13 interacts with MDA5 and negatively regulates MDA5-mediated type I IFN production PMID:25008915
14. RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication. PMID:24039580
15. MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung. PMID:24417465
16. These results strongly suggest that RIG-I and MDA5 participate in innate antiviral responses in cochlear tissue. PMID:23644230
17. These studies suggest that MDA5 in the immune priming environment shapes optimal CD8(+) T cell activation and subsequent clearance of West Nile virus from the central nervous system. PMID:23966390
18. Thus, RIG-I and MDA5 are essential pattern recognition receptors that recognize distinct pathogen-associated molecular patterns that accumulate during West Nile virus replication. PMID:23966395
19. Collectively, our in vitro and in vivo studies both support a critical role for MDA5 in the innate immune response against hepatitis B virus infection. PMID:23926323
20. these findings suggest that mast cells produce cytokines and chemokines in the early infection stage after recognizing viruses via RIG-I and MDA5, and may contribute to antiviral responses PMID:23171655
21. MDA5 localization to stress granules is not required for the induction of interferon alpha and beta during mengovirus infection PMID:23536668
22. Myocardial MDA5 may be a key molecule in protecting the heart from direct viral injury and myocardial dysfunction. PMID:23271791
23. MDA5 is a polymerization-dependent signaling platform that uses the amyloid-like self-propagating properties of mitochondrial antiviral-signaling protein to amplify signaling. PMID:23090998
24. Pretreatment of mice with melanoma differentiation-associated gene 5 (MDA5) and IFN-beta promoter stimulator-1 ASOs. PMID:22505629
25. MDA5 overexpression led to a chronic IFN-I state characterized by resistance to a lethal viral infection through rapid clearance of virus in the absence of a CD8(+) or Ab response PMID:22205024
26. It was shown that MDA5 cooperatively binds short RNA ligands as a dimer with a 16-18-basepair footprint. A crystal structure of the MDA5 helicase-insert domain demonstrates an evolutionary relationship with the archaeal Hef helicases. PMID:22314235
27. However, only MDA5 interacted with the V protein dependently on the C-terminal V unique (Vu) region, inhibiting IRF3 reporter activation. PMID:21851384
28. MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PMID:21637773
29. Signaling through melanoma differentiation-associated (MDA)5 and RIG-I controls rotavirus production in intestinal epithelial cells. PMID:21187438
30. These results demonstrate that mouse hepatitis virus is recognized by both RIG-I and MDA5 and induces IFN-alpha/beta through the activation of the IRF-3 signaling pathway. PMID:20427526
31. MDA-5 plays an important role in the host immune response to CVB3 by preventing early virus replication and limiting tissue pathology. PMID:20206372
32. MDA5 and Toll-like receptor 3 mediate substantially distinct yet complementary functions during polyinosinic:polycytidylic acid (poly I-C)-mediated activation of antigen-specific CD8 T cell responses. PMID:20164430
33. These findings indicate that changes in MDA5 and PTPN2 expression modify beta-cell responses to dsRNA. PMID:19825843
34. data suggest that LGP2 facilitates viral RNA recognition by RIG-I and MDA5 through its ATPase domain. PMID:20080593
35. MDA5 is indispensable for sustained expression of IFN in response to paramyxovirus infection PMID:20107606
36. Two RNA-sensing proteins, RIG-I and MDA5, participate in the IFN response to Legionella pneumophila. PMID:19936053
37. stimulation with RNA viruses encephalomyocarditis virus and Sendai virus specifically activates MDA5 and RIG-I, blocking Treg cell function PMID:19966212
38. MDA5 and its adaptor molecule MAVS are critical for type I interferon responses to CVB; the absence of either MAVS or MDA5 leads to deficient type I interferon production and early mortality PMID:19846534
39. Data show that viral RNA stimulates glomerular mesangial cells to produce large amounts of type I IFN, especially when being delivered into the intracellular cytosol where it can interact with Mda5. PMID:19850889
40. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. PMID:16116171
41. RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection PMID:16625202
42. mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo PMID:16714379
43. These observations demonstrate differential and redundant roles for RIG-I and MDA5 in pathogen recognition and innate immune signaling. PMID:17942531
44. RIG-I and MDA5 are responsible for triggering downstream gene expression in response to West Nile Virus infection by signaling through IPS-1. PMID:17977974
45. offer biological relevance to the previously reported inhibition of MDA5 by different paramyxovirus V proteins PMID:18354215
46. Collectively, RIG-I detects dsRNAs without a 5'-triphosphate end, and RIG-I and MDA5 selectively recognize short and long dsRNAs, respectively. PMID:18591409
47. Data suggest that mouse hepatitis virus induces type I interferon in macrophages and microglia in the brain and is recognized by an MDA5-dependent pathway in macrophages. PMID:18667505
48. Astrocytes recognize intracellular poly I-C via MDA-5. PMID:19036857
49. activation of the virus-sensing MDA-5 receptor leads to a rapid and reversible involution of the thymus PMID:19414755
50. two RIG-I-like receptors (RLRs), RIG-I and MDA5, known as cytosolic RNA receptors, nonredundantly function as cytosolic DNA receptors that lead to the selective activation of type I IFN genes PMID:19805092

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UNIGENE: Mm.136224

KEGG: mmu:71586

STRING: 10090.ENSMUSP00000028259