Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Value-added Deliverables
① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.
Gene References into Functions
both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms.PMID:28341548
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in DrosophilaPMID:24339784
zebrafish Costal2 acts as an intracellular repressor of signal transductionPMID:15647323
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Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF27 subfamily