MRE11 Antibody

Code: CSB-PA339299XA01SVG

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0.1ml

0.1ml1ml

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Species Reactivity: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P32829

Target Names

MRE11

Alternative Names

MRE11 antibody; YMR224C antibody; YM9959.06C antibody; Double-strand break repair protein MRE11 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRE11 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Gene References into Functions

error-prone BIRs are increased in homeologous recombination in wild-type and in mre11A470T cells. PMID:29705126
Resection of DNA breaks is impaired when either Sae2 activity is blocked, suggesting roles for both Mre11 and Sae2 nuclease activities in promoting the processing of DNA ends in vivo. PMID:28970327
A major DSB sensor, the Mre11-Rad50-Xrs2 (MRX) complex, is regulated by cell cycle-dependent phosphorylation specifically in mitosis. PMID:24553123
propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection PMID:21876003
results identify a function for MRE11 in the response to topoisomerase poisons that is distinct from its functions in DSB repair or meiotic DNA processing PMID:21060845
Mre11 mutation promotes telomere recombination and an efficient bypass of senescence. PMID:20421597
Mre11 nuclease activity is essential for resection in the absence of extensive double-strand break end resection enzymes. PMID:20834227
Mre11 mutations are associated with increased rates of spontaneous loss of heterozygosity leading to genome instability. PMID:20410660
The nuclease function of Mre11 is required for RMX-mediated recombinational repair and telomere stabilization in mitotic cells. PMID:15126391
Mre11 nuclease is not involved in the extensive 5' to 3' resection of double-strand breaks PMID:15485933
Rad50 hook is critical for Mre11 complex-dependent DNA repair, telomere maintenance and meiotic double-strand break formation PMID:15852023
Srs2 and Sgs1 associate with Mre11 in different subcomplexes following checkpoint abd CDK1-mediated Srs2 phosphorylation. PMID:15964827
These data suggest that Mre 11p can act as a positive and negative regulator of TRD in context of the MRX complex that is essential for TRD. PMID:15990364
S.cerevisiae Mre11 protein possesses high binding affinity for G4 DNA and cleaves G-rich sequences. PMID:16116037
Mutations in Mre11 phosphoesterase motif I impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. PMID:16143598
Mre11/Rad50 complexes from three organisms catalyze the reversible adenylate kinase reaction in vitro. PMID:17349953
Mre11 is involved in the regulation of a specific class of genes during spore development through its C-terminus domain. PMID:17396017
Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing. PMID:18335232